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Título: | Grape seed extract (GSE) modulates campylobacter pro-inflammatory response in human intestinal epithelial cell lines |
Autor: | Silván, José Manuel CSIC ORCID ; Mingo, Elisa CSIC; Martínez-Rodríguez, Adolfo J. CSIC ORCID | Palabras clave: | Campylobacter Inflammation GSE Cytokines |
Fecha de publicación: | 2017 | Editor: | Taylor & Francis | Citación: | Food and Agricultural Immunology 28(5): 739-753 (2017) | Resumen: | The main aim of this study was to investigate the effect of Grape seed extract (GSE) on Campylobacter induced-cytokine production by human intestinal cell lines. With this purpose, Caco-2 and HT-29 cells were challenged with culture supernatants from several strains of C. jejuni and levels of secreted IL-6, IL-8, and MCP-1 were measured. Cytokine production was higher in HT-29 than in Caco-2 cells, showing different levels of secretion depending of the epithelial cells origin. Also, infective isolates coming from campylobacteriosis patients rendered higher levels of pro-inflammatory cytokines. Co-treatment and pre-treatment of HT-29 cells with GSE and C. jejuni significantly reduced cytokines production in a dose-dependent manner. These results make this natural product a putative nutritional tool for use in the treatment of campylobacteriosis, which could contribute to improve disease prevention or reduce disease severity. | Versión del editor: | https://doi.org/10.1080/09540105.2017.1312292 | URI: | http://hdl.handle.net/10261/194112 | DOI: | 10.1080/09540105.2017.1312292 | ISSN: | 0954-0105 | E-ISSN: | 1465-3443 |
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