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Título

Grape seed extract (GSE) modulates campylobacter pro-inflammatory response in human intestinal epithelial cell lines

AutorSilván, José Manuel CSIC ORCID ; Mingo, Elisa CSIC; Martínez-Rodríguez, Adolfo J. CSIC ORCID
Palabras claveCampylobacter
Inflammation
GSE
Cytokines
Fecha de publicación2017
EditorTaylor & Francis
CitaciónFood and Agricultural Immunology 28(5): 739-753 (2017)
ResumenThe main aim of this study was to investigate the effect of Grape seed extract (GSE) on Campylobacter induced-cytokine production by human intestinal cell lines. With this purpose, Caco-2 and HT-29 cells were challenged with culture supernatants from several strains of C. jejuni and levels of secreted IL-6, IL-8, and MCP-1 were measured. Cytokine production was higher in HT-29 than in Caco-2 cells, showing different levels of secretion depending of the epithelial cells origin. Also, infective isolates coming from campylobacteriosis patients rendered higher levels of pro-inflammatory cytokines. Co-treatment and pre-treatment of HT-29 cells with GSE and C. jejuni significantly reduced cytokines production in a dose-dependent manner. These results make this natural product a putative nutritional tool for use in the treatment of campylobacteriosis, which could contribute to improve disease prevention or reduce disease severity.
Versión del editorhttps://doi.org/10.1080/09540105.2017.1312292
URIhttp://hdl.handle.net/10261/194112
DOI10.1080/09540105.2017.1312292
ISSN0954-0105
E-ISSN1465-3443
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