Please use this identifier to cite or link to this item:
Título : A new approach to enantiopure β-endo-substituted azabicyclic proline analogues by base induced epimerization of a formyl derivative
Autor : Gil, Alejandrona M., Buñuel, Elena, Cativiela, Carlos
Palabras clave : Constrained proline
α-amino acids
Fecha de publicación : Sep-2006
Editor: Arkat USA
Citación : Arkivoc (IV): 157-169 (2007)
Resumen: The β-epimer of methyl (1S,2R,4R)-N-benzoyl-2-formyl-7-azabicyclo[2.2.1]heptane-1- carboxylate, (1S, 2S, 4R)-7, has been obtained by treatment of the exo-formyl derivative with triethylamine in methanol. The development of this epimerization procedure has further increased the already wide possibilities offered by our methodology and solves the problem of access to the endo derivatives that would result from the Diels–Alder reaction of Danishefsky’s diene and the C-4 unsaturated E-oxazolones, whose preparation frequently proves to be problematic.
Descripción : 13 pages, 6 schemes, 1 figure.
Versión del editor:
ISSN: 1551-7004 (Print)
1424-6376 (Online)
Citación : Arkivoc (IV): 157-169 (2007)
Appears in Collections:(ICMA) Artículos

Files in This Item:
File Description SizeFormat 
http___www.arkat-usa.pdf319,84 kBAdobe PDFView/Open
Show full item record

Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.