English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/193405
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

"Customizable" units in Di- and tripeptides: Selective conversion into substituted dehydroamino acids

AuthorsSaavedra, Carlos J.; Boto, Alicia ; Hernández, Rosendo
KeywordsSelective conversion
Dehydroamino acids
Di- and Tripeptides
Issue Date11-Jul-2012
PublisherACS Publications
CitationOrganic Letters 14(14): 3788-3791 (2012)
AbstractThe selective conversion of serine or threonine units of di- and tripeptides into substituted dehydroamino acids is reported. Thus, these common α-amino acids undergo a scission-phosphorylation process to give α-amino phosphonate residues. A Horner-Wadsworth-Emmons reaction with aldehydes or ketones follows to afford the final products with excellent Z-stereoselectivity (Z:E > 98:2). In this way, a single peptide precursor can selectively be transformed into a variety of derivatives.
Publisher version (URL)https://pubs.acs.org/doi/10.1021/ol301676z
URIhttp://hdl.handle.net/10261/193405
Identifiersdoi: 10.1021/ol301676z
issn: 1523-7060
e-issn: 1523-7052
Appears in Collections:(IPNA) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.