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http://hdl.handle.net/10261/193399
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Johansen, Matt D. | es_ES |
dc.contributor.author | Hortle, Elinor | es_ES |
dc.contributor.author | Kasparian, Joshua A. | es_ES |
dc.contributor.author | Romero Jódar, Alejandro | es_ES |
dc.contributor.author | Novoa, Beatriz | es_ES |
dc.contributor.author | Figueras Huerta, Antonio | es_ES |
dc.contributor.author | Britton, Warwick J. | es_ES |
dc.contributor.author | de Silva, Kumudika | es_ES |
dc.contributor.author | Purdie, Auriol C. | es_ES |
dc.contributor.author | Oehlers, Stefan H. | es_ES |
dc.date.accessioned | 2019-10-25T08:17:43Z | - |
dc.date.available | 2019-10-25T08:17:43Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Fish and Shellfish Immunology 83: 238-242 (2018) | es_ES |
dc.identifier.issn | 1050-4648 | - |
dc.identifier.uri | http://hdl.handle.net/10261/193399 | - |
dc.description | 5 pages, 4 figures | es_ES |
dc.description.abstract | Changes to lipid metabolism are well-characterised consequences of human tuberculosis infection but their functional relevance are not clearly elucidated in these or other host-mycobacterial systems. The zebrafish-Mycobacterium marinum infection model is used extensively to model many aspects of human-M. tuberculosis pathogenesis but has not been widely used to study the role of infection-induced lipid metabolism. We find mammalian mycobacterial infection-induced alterations in host Low Density Lipoprotein metabolism are conserved in the zebrafish model of mycobacterial pathogenesis. Depletion of LDLR, a key lipid metabolism node, decreased M. marinum burden, and corrected infection-induced altered lipid metabolism resulting in decreased LDL and reduced the rate of macrophage transformation into foam cells. Our results demonstrate a conserved role for infection-induced alterations to host lipid metabolism, and specifically the LDL-LDLR axis, across host-mycobacterial species pairings | es_ES |
dc.description.sponsorship | This work was supported by the Australian National Health and Medical Research Council (APP1099912 and APP1053407 to S.H.O.); Meat and Livestock Australia (P.PSH. 0813 to A.C.P. and K. dS); the Marie Bashir Institute for Infectious Diseases and Biosecurity (grant to S.H.O., A.C.P. and K. dS); the Kenyon Family Foundation Inflammation Award (grant to S.H.O.); the University of Sydney (fellowship to S.H.O.); Consellería de Economía, Emprego e Industria (GAIN), Xunta de Galicia (grant IN607B 2016/12 to Institute of Marine Research (IIM-CSIC)) | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation.isversionof | Postprint | es_ES |
dc.rights | openAccess | en_EN |
dc.subject | Zebrafish | es_ES |
dc.subject | Mycobacterium | es_ES |
dc.subject | Lipid | es_ES |
dc.subject | Granuloma | es_ES |
dc.subject | Pathogenesis | es_ES |
dc.title | Analysis of mycobacterial infection-induced changes to host lipid metabolism in a zebrafish infection model reveals a conserved role for LDLR in infection susceptibility | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1016/j.fsi.2018.09.037 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.fsi.2018.09.037 | es_ES |
dc.identifier.e-issn | 1095-9947 | - |
dc.embargo.terms | 2019-12-01 | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.languageiso639-1 | en | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.openairetype | artículo | - |
Aparece en las colecciones: | (IIM) Artículos |
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Analysis_micobacterial_2018.pdf | 1,71 MB | Adobe PDF | Visualizar/Abrir |
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