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Title

Analysis of mycobacterial infection-induced changes to host lipid metabolism in a zebrafish infection model reveals a conserved role for LDLR in infection susceptibility

AuthorsJohansen, Matt D.; Hortle, Elinor; Kasparian, Joshua A.; Romero Jódar, Alejandro; Novoa, Beatriz ; Figueras Huerta, Antonio ; Britton, Warwick J.; de Silva, Kumudika; Purdie, Auriol C.; Oehlers, Stefan H.
KeywordsZebrafish
Mycobacterium
Lipid
Granuloma
Pathogenesis
Issue Date2018
PublisherElsevier
CitationFish and Shellfish Immunology 83: 238-242 (2018)
AbstractChanges to lipid metabolism are well-characterised consequences of human tuberculosis infection but their functional relevance are not clearly elucidated in these or other host-mycobacterial systems. The zebrafish-Mycobacterium marinum infection model is used extensively to model many aspects of human-M. tuberculosis pathogenesis but has not been widely used to study the role of infection-induced lipid metabolism. We find mammalian mycobacterial infection-induced alterations in host Low Density Lipoprotein metabolism are conserved in the zebrafish model of mycobacterial pathogenesis. Depletion of LDLR, a key lipid metabolism node, decreased M. marinum burden, and corrected infection-induced altered lipid metabolism resulting in decreased LDL and reduced the rate of macrophage transformation into foam cells. Our results demonstrate a conserved role for infection-induced alterations to host lipid metabolism, and specifically the LDL-LDLR axis, across host-mycobacterial species pairings
Description5 pages, 4 figures
Publisher version (URL)https://doi.org/10.1016/j.fsi.2018.09.037
URIhttp://hdl.handle.net/10261/193399
DOI10.1016/j.fsi.2018.09.037
ISSN1050-4648
E-ISSN1095-9947
Appears in Collections:(IIM) Artículos
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