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Título: | Inflammation in metabolically healthy and metabolically abnormal adolescents: The HELENA study |
Autor: | González-Gil, Esther; Cadenas-Sanchez, Cristina; Santabárbara, Javier; Bueno, Gloria; Iglesia, Iris; González-Gross, Marcela CSIC ORCID; Molnár, Dénes; Gottrand, Frederic; De Henauw, Stefaan; Cañada, David; Censi, Laura; Kersting, Mathilde; Dallongeville, Jean; Marcos, Ascensión CSIC ORCID; Ortega, F. B.; Moreno, Luis A. | Fecha de publicación: | 2018 | Editor: | Elsevier | Citación: | Nutrition, Metabolism and Cardiovascular Diseases 28(1): 77-83 (2018) | Resumen: | [Background and aims] Inflammation may influence the cardio-metabolic profile which relates with the risk of chronic diseases. This study aimed to assess the inflammatory status by metabolic health (MH)/body mass index (BMI) category and to assess how inflammatory markers can predict the cardio-metabolic profile in European adolescents, considering BMI. [Methods and results] A total of 659 adolescents (295 boys) from a cross-sectional European study were included. Adolescents were classified by metabolic health based on age- and sex-specific cut-off points for glucose, blood pressure, triglycerides, high density cholesterol and BMI. C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α), interleukin (IL-6), complement factors (C3, C4) and cell adhesion molecules were assessed. [Results] Metabolically abnormal (MA) adolescents had higher values of C3 (p < 0.001) and C4 (p = 0.032) compared to those metabolically healthy (MHy). C3 concentrations significantly increased with the deterioration of the metabolic health and BMI (p < 0.001). Adolescents with higher values of CRP had higher probability of being in the overweight/obese-MH group than those allocated in other categories. Finally, high C3 and C4 concentrations increased the probability of having an unfavorable metabolic/BMI status. [Conclusions] Metabolic/BMI status and inflammatory biomarkers are associated, being the CRP, C3 and C4 the most related inflammatory markers with this condition. C3 and C4 were associated with the cardio-metabolic health consistently. | Descripción: | On behalf of the HELENA study group. | Versión del editor: | https://doi.org/10.1016/j.numecd.2017.10.004 | URI: | http://hdl.handle.net/10261/192593 | DOI: | 10.1016/j.numecd.2017.10.004 | Identificadores: | doi: 10.1016/j.numecd.2017.10.004 e-issn: 1590-3729 issn: 0939-4753 |
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