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Título: | Serum metabolome of fasted gilthead sea bream. A non-targeted approach for the identification of robust biomarkers of malnutrition in fish |
Autor: | Gil-Solsona, Rubén ; Nácher-Mestre, Jaime CSIC ORCID; Sancho, Juan Vicente; Calduch-Giner, Josep A. CSIC ORCID; Hernández Hernández, Félix; Pérez-Sánchez, Jaume CSIC ORCID | Fecha de publicación: | 2017 | Editor: | Universidad Jaume I | Citación: | Advances in comparative endocrinology: vol. VIII: 59-62 (2017) | Resumen: | The study assessed the metabolomic fingerprinting of fasted gilthead sea bream by means of ultra-high performance liquid chromatography (LC) coupled to quadrupole time-of-flight mass spectrometry (QTOF MS). More than 15,000 different m/z ions were represented in the analyzed samples and discriminant analysis (PLS-DA) allowed a clear differentiation between the two experimental groups (fed and 10-days fasted fish), explaining the first component more than 90% of total variance. The most significant metabolites (up to 45) were elucidated based on their tandem MS (MS/MS) spectra with a broad representation of amino acids, oligopeptides, urea cycle metabolites, Lcarnitine-related metabolites, glutathione-related metabolites, fatty acids, lysophosphatidic acids, phosphatidylcholines, and biotine and noradrenaline metabolites. This highlighted important adaptive response in energy and oxidative metabolism, contributing this non-targeted approach to identify robust and nutritionallyregulated biomarkers of health and metabolic condition in farmed fish | Descripción: | Trabajo presentado en el 11º Congreso de la Asociación Ibérica de Endocrinología Comparada (AIEC), celebrado en Vigo (España), del 13 al 15 de julio de 2017 | URI: | http://hdl.handle.net/10261/192345 | ISBN: | 978-84-16356-88-1 |
Aparece en las colecciones: | (IATS) Libros y partes de libros |
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