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Possible role of central the melanocortin system in the control of circadian locomotor activity rhythms

AuthorsSoletto, L.; Puchol, Sara; Míguez, Jesús M.; Rotllant, Josep ; Rosel, J. F.; Cerdá-Reverter, José Miguel
Issue Date2017
PublisherUniversidad Jaume I
CitationAdvances in comparative endocrinology: vol. VIII: 156-158 (2017)
AbstractThe melanocortin system integrates peptides derived from proopiomelanocortin that show melanocortinic and/or corticotropic activity. Endogenous melanocortin antagonists, agouti-signaling protein (ASIP) and agouti-related protein (AGRP) compete with melanocortin peptide for binding to five different melanocortin receptors (MC1RMC5R). In zebrafish, AGRP and MC5R are duplicated. AGRP1 is specifically expressed in the hypothalamus but AGRP2 is expressed in the pineal. AGPR2 modulates the expression of the melanin-concentrating hormone (MCH) that is involved in the background adaptation. The expression of AGRP2 in the zebrafish pineal gland suggests the involvement of the melanocortin system in the regulation of circadian rhythms. We use a zebrafish transgenic strain overexpressing ASIP (Ag zebrafish) to study the role of melanocortin antagonist in the circadian structure of fish. We demonstrate that both diurnal and nocturnal melatonin levels in Ag zebrafish are statistically similar. Accordingly, comparison of brain transcriptome between Ag and wild type (WT) zebrafish revealed a significant enrichment of tryptophan and circadian rhythms go terms. Finally, the analysis of daily locomotor activity exhibited significant differences between Ag and WT fish further supporting a role for melanocortin system in the activity rhythms of zebrafish.
DescriptionTrabajo presentado en el 11º Congreso de la Asociación Ibérica de Endocrinología Comparada (AIEC), celebrado en Vigo (España), del 13 al 15 de julio de 2017
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