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Melanocortin receptor accesory proteins (MRAPs) participation in the fish melanocortin system

AuthorsCortés, Raúl ; Agulleiro Gozalbo, Maria Josep ; Michel, M.; Navarro, S. ; Sánchez, Elisa ; Soletto, L.; Cone, R. D.; Cerdá-Reverter, José Miguel
Issue Date2017
PublisherUniversidad Jaume I
CitationAdvances in comparative endocrinology: vol. VIII: 153-155 (2017)
AbstractOur previous studies have demonstrated the presence of three melanocortin receptor accessory proteins (MRAPs) in the zebrafish genome (MRAP1, MRPA2a and MRAP2b) and function of MRAP2s is unknown. Here, we demonstrate that both MRAP2s are coexpressed with MC4R in same neurons. Immunoprecipitation studies show also a physical interaction between MC4R and MRAP2s that is able to change pharmacological properties of the receptor. In addition, we have demonstrated that intraperitoneal ACTH1-24 reduces food intake levels via MC4R. Using CRISPR/Cas9 system we have successfully deleted MRAP2a from zebrafish genome and we have refused the involvement of MRAP2a in the larval growth as previously suggested.
DescriptionTrabajo presentado en el 11º Congreso de la Asociación Ibérica de Endocrinología Comparada (AIEC), celebrado en Vigo (España), del 13 al 15 de julio de 2017
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