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Effect of supplementation with tribasic zinc or copper salts on the liver antioxidant status in rats with fasciolosis

AutorManga-González, M. Yolanda ; Gabrashanska, M.; Ermidou-Pollet, S.; Mizinska, Y.; González Lanza, Camino ; Anisimova, M.
Fecha de publicaciónjun-2007
CitaciónThird International Conference "Bacterial, Viral and Parasitic Infections in Human and Veterinary Medicine" pag.54 (2007)
ResumenRecent studies indicate that fasciolosis leads to oxidative stress which is the causative agent in the initiation and progress of lipid peroxidation in the host. Many antioxidant defences depend on micronutrients (Cu, Zn, Mn, Se) or are micronutrients themselves. The aim of our study was to assess the antioxidant status (vitamin C, A, E, zinc, copper, superoxide dismutase and catalase activity and malonildialdehyde content) of rat liver in the chronic stage of fasciolosis after supplementation with tribasic zinc or copper chloride [Cu2(OH)3Cl and Zn5(OH)3Cl]. Levels of vitamins and trace elements as well as SOD-activity were reduced and CAT-activity increased in the infected livers. The application of Zn5(OH)3Cl elevated the concentration of vitarnin E, C and A, and Zn, and the activity of SOD without affecting CAT-activity. The application of Cu2(OH)3Cl increased the concentration of Cu and vitamin E without affecting CAT and SOD-activity. Both salts reduced liver malonildialdehyde content. The effect of salts vas better expressed on the antioxidant parameters in the infected animals than in the control ones. Results indicate that the antioxidant imbalance was developed in the livers of rats infected with F. hepatica. The application of both basic salts improves the host’s antioxidant defence system. It seems that Zn5(OH)3Cl is a more potent antioxidant than Cu2(OH)3Cl in the rats with fasciolosis. Food fortification with an adequate zinc and copper compound would be an economical strategy to prevent zinc and/or copper deficiency leading to increased oxidative stress in parasitoses.
Descripción1 page.-- Contributed to Third International Conference "Bacterial, Viral and Parasitic Infections in Human and Veterinary Medicine", Medical University, Sofia, Bulgaria, June 15-16, 2007
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