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dc.contributor.authorVélez, Emilioes_ES
dc.contributor.authorAzizi, Sheidaes_ES
dc.contributor.authorCalduch-Giner, Josep A.es_ES
dc.contributor.authorPérez-Sánchez, Jaumees_ES
dc.contributor.authorNavarro, Isabeles_ES
dc.contributor.authorFernández-Borràs, Jaumees_ES
dc.contributor.authorBlasco, Josefinaes_ES
dc.contributor.authorCapilla, E.es_ES
dc.contributor.authorGutiérrez, Joaquím-
dc.date.accessioned2019-09-26T12:03:15Z-
dc.date.available2019-09-26T12:03:15Z-
dc.date.issued2014-08-25-
dc.identifier.citation27th Conference of European Comparative Endocrinologists (2014)es_ES
dc.identifier.urihttp://hdl.handle.net/10261/191680-
dc.descriptionTrabajo presentado en la 27th Conference of European Comparative Endocrinologists, celebrada en Rennes (Francia), del 25 al 29 de agosto de 2014es_ES
dc.description.abstractIn vertebrates, the endocrine system regulates growth mainly through the growth hormone (GH)/insulin-like growth factors (IGFs) axis and, although exercise modulates growth, little is known about the response on these endocrine factors. The aim of this work was to characterize the effects of five weeks of moderate sustained swimming over the GH/IGFs axis and growth in gilthead sea bream juveniles. We analyzed the plasma GH and IGF-I levels and, the gene expression in liver and anterior and caudal muscles of: GH receptors (GHR1 and GHR2), three IGF-I splice variants (IGF-Ia/b/c), IGF-II, as well as for the first time in this species, that of the two IGF-I receptors (IGF-IRa and IGF-IRb). Fish under exercise (EX) grew significantly more than control fish (CT) without differences in feed intake. Moreover, plasma GH levels significantly decreased in EX fish in comparison with CT fish, together with reduced hepatic expression of both GHRs. GHR2 expression was also down-regulated in the anterior muscle, whereas GHR1 expression significantly increased in both muscle regions. These results indicated tissue-dependent differences of GHRs expression in response to exercise and suggest that GHR1 seems to be more important regulating muscle growth. On the other hand, plasma IGF-I levels in EX fish were significantly higher than those of CT fish, according to the increased IGF-I expression (mainly IGF-Ia) in the liver of the former. In both muscle regions, total IGF-I mRNA levels were similar; however, the expression of IGF-Ic increased significantly with exercise, suggesting a potential role for this splice variant mediating the swimming activity effects on muscle growth. Additionally, we found a significant up-regulation of IGFII expression in the caudal muscle region of EX fish, which may be related with the well-described local effects of this factor enhancing muscle growth. Furthermore, exercise decreased the hepatic IGF-IRa expression levels, while IGF-IRb was not detectable, showing a similar regulation as that observed for the GHRs. Contrary in muscle, both IGF-IRs were present, although their gene expression levels remained unchanged with exercise. Altogether, these data indicate that moderate sustained activity may be used to increase the IGF-I/GH ratio in plasma and, to modulate the muscle gene expression of different molecules of the GH/IGFs axis (i.e. GHR1 and IGF-II), to potentiate growth in gilthead sea bream.es_ES
dc.language.isoenges_ES
dc.rightsclosedAccesses_ES
dc.titleSustained exercise effects on GH/IGFs axis and growth in gilthead sea bream (Sparus aurata)es_ES
dc.typepóster de congresoes_ES
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.contributor.orcidCalduch-Giner, Josep A. [0000-0003-3124-5986]es_ES
dc.type.coarhttp://purl.org/coar/resource_type/c_6670es_ES
item.openairetypepóster de congreso-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
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