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Gonadotropin sialylation in European sea bass (Dicentrarchus labrax), another way of activity regulation?

AuthorsMolés, Gregorio ; Zapater, Cinta ; Zanuy, Silvia ; Gómez, Ana
KeywordsFollicle Stimulating Hormone
Gonadotropin activity regulation
Issue Date4-Sep-2017
Citation6th International Workshop on the Biology of Fish Gametes (2017)
AbstractThe pituitary gland synthesizes and secrets differently glycosylated forms of gonadotropins that differ in their oligosaccharide structure. In the case of FSH, several enzymes are involved in its post-translational glycosylation processing; particularly the sialyltransferases (STs) that transfer sialic acid residues into the FSH carbohydrate chain. Previous studies with recombinant sea bass Fsh showed that, as occurs in mammals, less sialylated isoforms exhibit higher in-vitro biological activity but shorter plasma half-life than their more sialylated counterparts. These facts suggest that gonadotropin heterogeneity represents an alternative mechanism of the pituitary gland to regulate the intensity and duration of gonadotropin stimuli in the gonads. In addition, the composition of the FSH carbohydrate moiety is likely regulated by the endocrine milieu, and the GnRH and gonadal sex steroids have been proposed as the main regulators of FSH microheterogeneity. Our aim in this study was to know the expression profile of several sea bass ST genes in male pituitary during a whole reproductive cycle and to elucidate whether treatments with gonadal steroids (Estradiol, Testosterone, Dihydroxyprogesterone) and LHRHa can affect the expression of these genes in a pituitary primary cell culture, and therefore to the potential sialylation of sea bass Fsh.
DescriptionTrabajo presentado en el 6th International Workshop on the Biology of Fish Gametes, celebrado en Vodňany (República Checa), del 4 al 7 de septiembre de 2017
Appears in Collections:(IATS) Comunicaciones congresos
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