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Título: | An efficient and practical method for the enantioselective synthesis of tertiary trifluoromethyl carbinols |
Autor: | Borrego, Lorenzo G.; Recio, Rocío; Alcarranza, M.; Khiar el Wahabi, Noureddine CSIC ORCID; Fernández Fernández, Inmaculada | Palabras clave: | Tertiary trifluoromethyl carbinols Enantioselective rhodium-catalysed arylation Shelf-stable ligand Cost effective synthetic approximation Chiral sulfinamide-olefin |
Fecha de publicación: | 20-mar-2018 | Editor: | John Wiley & Sons | Citación: | Advanced Synthesis and Catalysis 360(6): 1273-1279 (2018) | Resumen: | An efficient sulfinamide/olefin based chiral ligand, MetSulfolefin, has been developed for the enantioselective rhodium-catalysed addition of aryl-boronic acids to trifluoromethyl ketones. This shelf-stable ligand is insensitive to air, oxygen and moisture, and it is obtained in only two high yielding steps from cheap commercially available (R)-tert-butanesulfinamide. The new ligand tolerates the use of hindered boronic acids and leads to the formation of a series of chiral trifluoromethyl-substituted tertiary carbinols in high yields and excellent enantioselectivities (up to >99% ee). (Figure presented.). | Versión del editor: | https://doi.org/10.1002/adsc.201701212 | URI: | http://hdl.handle.net/10261/190580 | DOI: | 10.1002/adsc.201701212 | ISSN: | 1615-4150 | E-ISSN: | 1615-4169 |
Aparece en las colecciones: | (IIQ) Artículos |
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