Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/19049
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Title

Novel epicatechin derivatives with antioxidant activity modulate interleukin-1β release in lipopolysaccharide-stimulated human blood

AuthorsMitjans, Montserrat; Martínez, Verónica; Campo, Jaime del; Abajo, Celia; Lozano, Carles; Torres, Josep Lluís CSIC ORCID; Vinardell, M. Pilar CSIC ORCID
KeywordsEpicatechin derivatives
Grape polymeric flavanols
Antioxidant
Interleukin-1β
Hemolysis
Issue Date1-Sep-2004
PublisherElsevier
CitationBioorganic and Medicinal Chemistry Letters 14(20): 5031-5034 (2004).
AbstractWe examine the potential antioxidant activity and the immune function of new epicatechin conjugates obtained by depolymerization of grape polymeric flavanols in the presence of cysteamine or cysteine. When incubated with an erythrocyte suspension, flavanols protected the erythrocyte membrane from hemolysis induced by 2,2′-azo-bis(2-amidinopropane)dihydrochloride (AAPH), an azo free radical initiator. The inhibitory effect was concentration-dependent and the IC50 was 119.8 μM for epicatechin, and 74.9 and 89.4 μM for the cysteine and cysteamine derivatives, respectively. These compounds were tested for their antioxidant activity and their capacity to modulate interleukin-1β (IL-1β), which is currently considered to be the major cytokine factor influencing the acute phase of the inflammatory response. At concentrations up to 20 μM, epicatechin and its derivatives inhibited the production of IL-1β in whole blood incubated in the presence of E. coli lipopolysaccharide (LPS), in a concentration-dependent manner. The most active compound was the cysteamine derivative.
Description4 pages, 3 figures.-- PMID: 15380193 [PubMed].-- Printed version published Oct 18, 2004
Publisher version (URL)http://dx.doi.org/10.1016/j.bmcl.2004.08.004
URIhttp://hdl.handle.net/10261/19049
DOI10.1016/j.bmcl.2004.08.004
ISSN0960-894X
E-ISSN1464-3405
Appears in Collections:(IQAC) Artículos

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