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http://hdl.handle.net/10261/190262
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Perelló-Amorós, Miguel | es_ES |
dc.contributor.author | Vélez, Emilio | es_ES |
dc.contributor.author | Vela-Albesa, Jaume | es_ES |
dc.contributor.author | Sánchez-Moya, Albert | es_ES |
dc.contributor.author | Riera-Heredia, Natàlia | es_ES |
dc.contributor.author | Hedén, Ida | es_ES |
dc.contributor.author | Fernández-Borràs, Jaume | es_ES |
dc.contributor.author | Blasco, Josefina | es_ES |
dc.contributor.author | Calduch-Giner, Josep A. | es_ES |
dc.contributor.author | Navarro, Isabel | es_ES |
dc.contributor.author | Capilla, E. | es_ES |
dc.contributor.author | Jönsson, Elisabeth | es_ES |
dc.contributor.author | Pérez-Sánchez, Jaume | es_ES |
dc.contributor.author | Gutiérrez, Joaquím | - |
dc.date.accessioned | 2019-09-09T12:29:02Z | - |
dc.date.available | 2019-09-09T12:29:02Z | - |
dc.date.issued | 2018-07-30 | - |
dc.identifier.citation | Frontiers in Endocrinology 9: 399(2018) | es_ES |
dc.identifier.issn | 1664-2392 | - |
dc.identifier.uri | http://hdl.handle.net/10261/190262 | - |
dc.description.abstract | Ghrelin is involved in the regulation of growth in vertebrates through controlling different functions, such as feed intake, metabolism, intestinal activity or growth hormone (Gh) secretion. The aim of this work was to identify the sequences of preproghrelin and Ghrelin receptors (ghsrs), and to study their responses to different nutritional conditions in gilthead sea bream (Sparus aurata) juveniles. The structure and phylogeny of S. aurata preproghrelin was analyzed, and a tissue screening was performed. The effects of 21 days of fasting and 2, 5, 24 h, and 7 days of refeeding on plasma levels of Ghrelin, Gh and Igf-1, and the gene expression of preproghrelin, ghsrs and members of the Gh/Igf-1 system were determined in key tissues. preproghrelin and the receptors are well conserved, being expressed mainly in stomach, and in the pituitary and brain, respectively. Twenty-one days of fasting resulted in a decrease in growth while Ghrelin plasma levels were elevated to decrease at 5 h post-prandial when pituitary ghsrs expression was minimum. Gh in plasma increased during fasting and slowly felt upon refeeding, while plasma Igf-1 showed an inverse profile. Pituitary gh expression augmented during fasting reaching maximum levels at 1 day post-feeding while liver igf-1 expression and that of its splice variants decreased to lowest levels. Liver Gh receptors expression was down-regulated during fasting and recovered after refeeding. This study demonstrates the important role of Ghrelin during fasting, its acute down-regulation in the post-prandial stage and its interaction with pituitary Ghsrs and Gh/Igf-1 axis. | es_ES |
dc.description.sponsorship | The authors thank the personnel from the animal facilities at the School of Biology for the fish maintenance and to Piscimar for providing the fish. We also thank Prof. Jordi Garcia for his help on sequence analysis and primer design of Ghsrs. MP-A, EV, and NR-H are supported by predoctoral fellowships from the Ministerio de Economía y Competitividad (MINECO) BES-2016-078697, BES-2013-062949 and BES-2015-074654, respectively. This study was supported by the projects from the MINECO AGL2014-57974-R to IN and EC. and AGL2015-70679-R to JG, and the Xarxa de Referència d'R+D+I en Aqüicultura and the 2014SGR-01371 from the Generalitat de Catalunya. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Frontiers Media | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2015-70679-R | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2014-57974-R | es_ES |
dc.relation.isversionof | Publisher's version | es_ES |
dc.rights | openAccess | es_ES |
dc.subject | Ghrelin | es_ES |
dc.subject | GHSR1a | es_ES |
dc.subject | Growth hormone | es_ES |
dc.subject | IGF-1 | es_ES |
dc.subject | Fasting and refeeding | es_ES |
dc.title | Ghrelin and its receptors in Gilthead sea bream: nutritional regulation | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.3389/fendo.2018.00399 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.3389/fendo.2018.00399 | es_ES |
dc.rights.license | http://creativecommons.org/licenses/by-nc-sa/4.0/ | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | es_ES |
dc.contributor.funder | Generalitat de Catalunya | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100002809 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.contributor.orcid | Calduch-Giner, Josep A. [0000-0003-3124-5986] | es_ES |
dc.identifier.pmid | 30105002 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
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Ghrelin_receptors.pdf | 4,45 MB | Adobe PDF | Visualizar/Abrir |
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