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Title

Conjugation inhibitors and their potential use to prevent dissemination of antibiotic resistance genes in bacteria

AuthorsCabezón, Elena ; Cruz, Fernando de la ; Arechaga, Ignacio
KeywordsBacterial conjugation
Fatty acids
Antibiotic resistance
Type IV secretion systems
Inhibitors
Issue Date2017
PublisherFrontiers Media
CitationFrontiers in Microbiology 8: 2329 (2017)
AbstractAntibiotic resistance has become one of the most challenging problems in health care. Bacteria conjugation is one of the main mechanisms whereby bacteria become resistant to antibiotics. Therefore, the search for specific conjugation inhibitors (COINs) is of interest in the fight against the spread of antibiotic resistances in a variety of laboratory and natural environments. Several compounds, discovered as COINs, are promising candidates in the fight against plasmid dissemination. In this review, we survey the effectiveness and toxicity of the most relevant compounds. Particular emphasis has been placed on unsaturated fatty acid derivatives, as they have been shown to be efficient in preventing plasmid invasiveness in bacterial populations. Biochemical and structural studies have provided insights concerning their potential molecular targets and inhibitory mechanisms. These findings open a new avenue in the search of new and more effective synthetic inhibitors. In this pursuit, the use of structure-based drug design methods will be of great importance for the screening of ligands and binding sites of putative targets.
Publisher version (URL)https://doi.org/10.3389/fmicb.2017.02329
URIhttp://hdl.handle.net/10261/190038
Identifiersdoi: 10.3389/fmicb.2017.02329
e-issn: 1664-302X
Appears in Collections:(IBBTEC) Artículos
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