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dc.contributor.authorVélez, Emilioes_ES
dc.contributor.authorAzizi, Sheidaes_ES
dc.contributor.authorMillán-Cubillo, A.es_ES
dc.contributor.authorFernández-Borràs, Jaumees_ES
dc.contributor.authorBlasco, Josefinaes_ES
dc.contributor.authorChan, Shu Jines_ES
dc.contributor.authorCalduch-Giner, Josep A.es_ES
dc.contributor.authorPérez-Sánchez, Jaumees_ES
dc.contributor.authorNavarro, Isabeles_ES
dc.contributor.authorCapilla, E.es_ES
dc.contributor.authorGutiérrez, Joaquim-
dc.identifier.citationAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology 310(4): R313-R322 (2016)es_ES
dc.description.abstractThe endocrine system regulates growth mainly through the growth hormone (GH)/insulin-like growth factors (IGFs) axis and, although exercise promotes growth, little is known about its modulation of these factors. The aim of this work was to characterize the effects of 5 wk of moderate sustained swimming on the GH-IGFs axis in gilthead sea bream fingerlings. Plasma IGF-I/GH ratio and tissue gene expression of total IGF-I and three splice variants, IGF-II, three IGF binding proteins, two GH receptors, two IGF-I receptors, and the downstream molecules were analyzed. Fish under exercise (EX) grew more than control fish (CT), had a higher plasma IGF-I/GH ratio, and showed increased hepatic IGF-I expression (mainly IGF-Ia). Total IGF-I expression levels were similar in the anterior and caudal muscles; however, IGF-Ic expression increased with exercise, suggesting that this splice variant may be the most sensitive to mechanical action. Moreover, IGFBP-5b and IGF-II increased in the anterior and caudal muscles, respectively, supporting enhanced muscle growth. Furthermore, in EX fish, hepatic IGF-IRb was reduced together with both GHRs; GHR-II was also reduced in anterior muscle, while GHR-I showed higher expression in the two muscle regions, indicating tissue-dependent differences and responses to exercise. Exercise also increased gene and protein expression of target of rapamycin (TOR), suggesting enhanced muscle protein synthesis. Altogether, these data demonstrate that moderate sustained activity may be used to increase the plasma IGF-I/GH ratio and to potentiate growth in farmed gilthead sea bream, modulating the gene expression of different members of the GH-IGFs axis (i.e., IGF-Ic, IGF-II, IGFBP-5b, GHR-I, and TOR).es_ES
dc.description.sponsorshipE. J. Vélez and A. Millán-Cubillo are supported by a predoctoral fellowship from the Ministerio de Ciencia e Innovación (MICINN). This study was supported by the projects from the MICINN AGL2009-12427 and AGL2012-39768 to J. Gutiérrez, and the Xarxa de Refèrencia d’R+D+I en Aqüicultura and the SGR2009-00402 from the Generalitat de Catalunyaes_ES
dc.publisherAmerican Physiological Societyes_ES
dc.subjectGrowth hormonees_ES
dc.subjectGH receptorses_ES
dc.subjectIGF-I receptorses_ES
dc.subjectIGF binding proteinses_ES
dc.titleEffects of sustained exercise on GH-IGFs axis in gilthead sea bream (Sparus aurata)es_ES
dc.description.peerreviewedPeer reviewedes_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderGeneralitat de Catalunyaes_ES
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