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Title

A malonyl-based scaffold for conjugatable multivalent carbohydrate-bodipy presentations

AuthorsUriel, Clara ; Sola-Llano, Rebeca; Bañuelos, Jorge; Gómez, Ana M. ; López, J. Cristóbal
KeywordsTetravalent scaffold
BODIPY
Multivalent presentation
Monosaccharide
Conjugation
Glycosylation
Issue Date2019
PublisherMolecular Diversity Preservation International
CitationMolecules 24(11): 2050 (2019)
AbstractA concise synthetic route from methylmalonate to a tetravalent aliphatic scaffold has been developed. The ensuing tetra-tethered derivative is equipped with two hydroxyl groups, as well as orthogonal alkene and alkyne functionalities. The usefulness of the scaffold has been demonstrated with the preparation of two representative multivalent derivatives: (i) a tetravalent compound containing two D-mannose units, one fluorescent boron-dipyrromethene (BODIPY) dye and a suitably functionalized amino acid and (ii) by way of dimerization and saponification, a water-soluble tetramannan derivative containing two fluorescent BODIPY units. Additionally, photophysical measurements conducted on these derivatives support the viability of the herein designed single and double BODIPY-labeled carbohydrate-based clusters as fluorescent markers.
Publisher version (URL)http://doi.org/10.3390/molecules24112050
URIhttp://hdl.handle.net/10261/189036
DOI10.3390/molecules24112050
ISSN1420-3049
E-ISSN1420-3049
Appears in Collections:(IQOG) Artículos
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