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Impact of dietary lipoic acid supplementation on liver mitochondrial bioenergetics and oxidative status on normally fed Wistar rats

AuthorsValdecantos, M. P.; Pérez-Matute, P.; Prieto-Hontoria, P.; Moreno-Aliaga, María Jesús; Martínez, J. A.
KeywordsLipoic acid
Healthy rats
Isocaloric standard chow diet
Oxidative stress
Issue Date2019
PublisherTaylor & Francis
CitationInternational Journal of Food Sciences and Nutrition 15: 1-11 (2019)
AbstractThe aim of this study was to examine the effects of α-lipoic acid (α-LA) on liver mitochondrial bioenergetics and oxidative status for 8 weeks in normal-healthy animals. A pair-fed group was included to differentiate between α-LA direct effects and those changes due to reduced food intake. α-LA decreased body weight gain, liver weight and insulin levels with no differences compared to its pair-fed group. α-LA significantly reduced energy efficiency, the activity of the electron transport chain complexes and induced a lower efficiency of oxidative phosphorylation with reduced ATP production. α-LA supplementation directly decreased plasma triglycerides (TGs), free fatty acids and ketone bodies levels. A significant reduction in hepatic TG content was also observed. A significant up-regulation of Cpt1a, Acadl and Sirt3, all β-oxidation genes, along with a significant deacetylation of the forkhead transcription factor 3a (FOXO3A) was found in α-LA-treated animals. Thus, α-LA along with a standard chow diet has direct actions on lipid metabolism and liver by modulating mitochondrial function in normal-weight rats. These results should be taken into account when α-LA is administered or recommended to a healthy population.
Publisher version (URL)https://doi.org/10.1080/09637486.2019.1572716
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