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dc.contributor.authorSato, Roseli H.es_ES
dc.contributor.authorKosaka, Priscila M.es_ES
dc.contributor.authorOmori, Álvaro T.es_ES
dc.contributor.authorFerreira, Edgard A.es_ES
dc.contributor.authorPetri, Denise F. S.es_ES
dc.contributor.authorMalvar, Óscares_ES
dc.contributor.authorDomínguez, Carmen M.es_ES
dc.contributor.authorPini, Valerioes_ES
dc.contributor.authorAhumada, O.es_ES
dc.contributor.authorTamayo de Miguel, Francisco Javieres_ES
dc.contributor.authorCalleja, Montserrates_ES
dc.contributor.authorCunha, Rodrigo L. O. R.es_ES
dc.contributor.authorFiorito, Pablo A.es_ES
dc.date.accessioned2019-08-21T12:26:47Z-
dc.date.available2019-08-21T12:26:47Z-
dc.date.issued2019-07-15-
dc.identifier.citationBiosensors and Bioelectronics 137: 287-293 (2019)es_ES
dc.identifier.issn0956-5663-
dc.identifier.urihttp://hdl.handle.net/10261/188767-
dc.description.abstractHypervalent tellurium compounds have a particular reactivity towards thiol compounds which are related to their biological properties. In this work, this property was assembled to tellurium-functionalized surfaces. These compounds were used as linkers in the immobilization process of thiolated biomolecules (such as DNA) on microcantilever surfaces. The telluride derivatives acted as reversible binding agents due to their redox properties, providing the regeneration of microcantilever surfaces and allowing their reuse for further biomolecules immobilizations, recycling the functional surface. Initially, we started from the synthesis of 4-((3-((4-methoxyphenyl) tellanyl) phenyl) amino)-4-oxobutanoic acid, a new compound, which was immobilized on a silicon surface. In nanomechanical systems, the detection involved a hybridization study of thiolated DNA sequences. Fluorescence microscopy technique was used to confirm the immobilization and removal of the telluride-DNA system and provided revealing results about the potentiality of applying redox properties to chalcogen derivatives at surfaces.es_ES
dc.description.sponsorshipWe acknowledge the financial support from the CAPES for granting a postgraduate scholarship, the Multiuser Central Facilities (CEM-UFABC) and the Universidade Federal do ABC, Santo André, Brazil. This work was supported by the Spanish Science Ministry (MINECO) through project TEC2017-89765-R and by the European Union's Horizon 2020 research and innovation program under grant agreement No 731868–VIRUSCAN and European Research Council grant 681275 – LIQUIDMASS- ERC- CoG-2015. P M Kosaka acknowledges funding from the Fundación General CSIC ComFuturo Program. We thank Prof. Dr. Erick Leite Bastos from the Universidade de São Paulo, Brazil, for financially supporting the organics analysis (NMR and MS) and Prof. Dr. Willian Reis de Araujo from Unicamp, Brazil, Dr. Letícia Christina Pires Gonçalves and Dr. Nathana Barbosa Lopes for their help in the analysis.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relationMINECO/ICTI2013-2016/TEC2017-89765-Res_ES
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/731868es_ES
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/681275es_ES
dc.relation.isversionofPostprintes_ES
dc.rightsembargoedAccesses_ES
dc.subjectBiosensores_ES
dc.subjectMicrocantileveres_ES
dc.subjectChalcogen chemistryes_ES
dc.subjectSurface regenerationes_ES
dc.subjectNanomechanical biosensorses_ES
dc.subjectReversible immobilizationes_ES
dc.titleDevelopment of a methodology for reversible chemical modification of silicon surfaces with application in nanomechanical biosensorses_ES
dc.typeartículoes_ES
dc.identifier.doi10.1016/j.bios.2019.04.028-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.bios.2019.04.028es_ES
dc.contributor.funderCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil)es_ES
dc.contributor.funderUniversidade Federal do ABCes_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderEuropean Commissiones_ES
dc.contributor.funderEuropean Research Counciles_ES
dc.contributor.funderFundación General CSICes_ES
dc.contributor.funderUniversidade de São Pauloes_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100002322es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000781es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100006003es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100005639es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
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