English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/188686
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

A role for the Tgf-β/Bmp co-receptor Endoglin in the molecular oscillator that regulates the hair follicle cycle

AuthorsCalvo, María I.; Fernández-Martos, Sandra; Carrasco, Elisa; Moreno-Bueno, Gema ; Bernabéu, Carmelo ; Quintanilla, Miguel ; Espada, Jesús
KeywordsEndoglin
Hair follicle
Skin stem cells
Wnt/β-catenin
Tgf-β/Bmp/Smad
Issue Date2019
PublisherOxford University Press
CitationJournal of Molecular Cell Biology 11(1): 39-52 (2019)
AbstractThe hair follicle is a biological oscillator that alternates growth, regression, and rest phases driven by the sequential activation of the proliferation/differentiation programs of resident stem cell populations. The activation of hair follicle stem cell niches and subsequent entry into the growing phase is mainly regulated by Wnt/β-catenin signalling, while regression and resting phases are mainly regulated by Tgf-β/Bmp/Smad activity. A major question still unresolved is the nature of the molecular switch that dictates the coordinated transition between both signalling pathways. Here we have focused on the role of Endoglin (Eng), a key co-receptor for members of the Tgf-β/Bmp family of growth factors. Using an Eng haploinsufficient mouse model, we report that Eng is required to maintain a correct follicle cycling pattern and for an adequate stimulation of hair follicle stem cell niches. We further report that β-catenin binds to the Eng promoter depending on Bmp signalling. Moreover, we show that β-catenin interacts with Smad4 in a Bmp/Eng-dependent context and both proteins act synergistically to activate Eng promoter transcription. These observations point to the existence of a growth/rest switching mechanism in the hair follicle that is based on an Eng-dependent feedback cross-talk between Wnt/β-catenin and Bmp/Smad signals.
Publisher version (URL)https://doi.org/10.1093/jmcb/mjy051
URIhttp://hdl.handle.net/10261/188686
DOI10.1093/jmcb/mjy051
ISSN1674-2788
E-ISSN1759-4685
Appears in Collections:(IIBM) Artículos
Files in This Item:
File Description SizeFormat 
rolecycle.pdf1,73 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.