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Título: | The neurotoxic role of extracellular tau protein |
Autor: | Sebastián-Serrano, Álvaro CSIC ORCID; Diego-García, Laura de; Díaz-Hernández, Miguel | Palabras clave: | Alzheimer’s disease TNAP Muscarinic receptors Synaptopathy Tau |
Fecha de publicación: | 2018 | Editor: | Multidisciplinary Digital Publishing Institute | Citación: | International Journal of Molecular Sciences 19(4): E998 (2018) | Resumen: | Tauopathies are a class of neurodegenerative diseases associated with the microtubule-associated protein tau, with Alzheimer's disease (AD) being the most prevalent related disorder. Neurofibrillary tangles (NFTs) are one of the neuropathological hallmarks present in the brains of AD patients. Because NFTs are aberrant intracellular inclusions formed by hyperphosphorylated tau, it was initially proposed that phosphorylated and/or aggregated intracellular tau protein was causative of neuronal death. However, recent studies suggest a toxic role for non-phosphorylated and non-aggregated tau when it is located in the brain extracellular space. In this work, we will discuss the neurotoxic role of extracellular tau as well its involvement in the spreading of tau pathologies. | URI: | http://hdl.handle.net/10261/188496 | DOI: | 10.3390/ijms19040998 | ISSN: | 1661-6596 | E-ISSN: | 1422-0067 |
Aparece en las colecciones: | (IIBM) Artículos |
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neuroprote.pdf | 2,03 MB | Adobe PDF | Visualizar/Abrir |
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