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Título: | Impact of nucleos(t)ide reverse transcriptase inhibitors on blood telomere length changes in a prospective cohort of aviremic HIV-infected adults |
Autor: | Montejano, Rocío; Stella-Ascariz, Natalia; Monge, Susana; Bernardino, José I.; Pérez-Valero, Ignacio; Montes, Mª L.; Valencia, Eulalia; Martín-Carbonero, Luz; Moreno, Victoria; González-García, Juan; Rodriguez-Centeno, Javier CSIC ORCID; Rodes, Berta; Esteban Cantos, Andrexs; Alejos, Belen; Miguel, Rosa de; Arnalich, Francisco; Perona Abellón, Rosario CSIC ORCID; Arribas, José R. | Palabras clave: | HIV infection Antiretroviral therapy Tenofovir Suppressed Abacavir Telomerase Telomere length |
Fecha de publicación: | 2018 | Editor: | Oxford University Press | Citación: | Journal of Infectious Diseases 218(10): 1531-1540 (2018) | Resumen: | [Background]: Tenofovir is a potent inhibitor of human telomerase. The clinical relevance of this inhibition is unknown. [Methods]: A prospective cohort of human immunodeficiency virus (HIV)–infected participants with suppressed virological replication was recruited to compare whole-blood telomere length (measured by quantitative multiplex polymerase chain reaction analysis) in participants with current exposure to tenofovir disoproxil fumarate (TDF) to that in participants never exposed to TDF. [Results]: A total of 172 participants were included: 67 were in the TDF group, and 105 were in the non-TDF group (75 were receiving 2 nucleosides [of whom 69 were receiving abacavir], 25 were receiving a nucleos[t]ide reverse transcriptase inhibitor [N{t}RTI]–sparing regimen, and 5 were receiving lamivudine as the only nucleoside). After 2 years, the mean blood telomere length increased significantly in the whole cohort. The TDF group had significantly smaller gains in telomere length than the non-TDF group. In the analysis restricted to participants receiving N(t)RTIs, TDF exposure was not associated with an independent negative effect. In the non-TDF group, participants treated with 2 nucleosides also had significantly smaller gains in telomere length than those receiving N(t)RTI-sparing regimens or lamivudine as the only nucleoside. [Discussion]: In HIV-infected adults with prolonged virological suppression, treatment with TDF or abacavir was associated with smaller gains in blood telomere length after 2 years of follow-up. |
Versión del editor: | https://doi.org/10.1093/infdis/jiy364 | URI: | http://hdl.handle.net/10261/188221 | DOI: | 10.1093/infdis/jiy364 | ISSN: | 0022-1899 | E-ISSN: | 1537-6613 |
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