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http://hdl.handle.net/10261/187999
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dc.contributor.author | Ferrer-Mayorga, Gemma | es_ES |
dc.contributor.author | Gómez-López, Gonzalo | es_ES |
dc.contributor.author | Barbáchano, Antonio | es_ES |
dc.contributor.author | Fernández-Barral, Asunción | es_ES |
dc.contributor.author | Peña, Cristina | es_ES |
dc.contributor.author | Pisano, David G. | es_ES |
dc.contributor.author | Cantero, Marta | es_ES |
dc.contributor.author | Rojo, Federico | es_ES |
dc.contributor.author | Muñoz Terol, Alberto | es_ES |
dc.contributor.author | Larriba, María Jesús | es_ES |
dc.date.accessioned | 2019-08-12T06:40:46Z | - |
dc.date.available | 2019-08-12T06:40:46Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Gut 66(8): 1449-1462 (2017) | es_ES |
dc.identifier.issn | 0017-5749 | - |
dc.identifier.uri | http://hdl.handle.net/10261/187999 | - |
dc.description.abstract | [Objective]: Colorectal cancer (CRC) is a major health concern. Vitamin D deficiency is associated with high CRC incidence and mortality, suggesting a protective effect of vitamin D against this disease. Given the strong influence of tumour stroma on cancer progression, we investigated the potential effects of the active vitamin D metabolite 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) on CRC stroma. | es_ES |
dc.description.abstract | [Design]: Expression of vitamin D receptor (VDR) and two 1,25(OH)2D3 target genes was analysed in 658 patients with CRC with prolonged clinical follow-up. 1,25(OH)2D3 effects on primary cultures of patient-derived colon normal fibroblasts (NFs) and cancer-associated fibroblasts (CAFs) were studied using collagen gel contraction and migration assays and global gene expression analyses. Publicly available data sets (n=877) were used to correlate the 1,25(OH)2D3-associated gene signature in CAFs with CRC outcome. | es_ES |
dc.description.abstract | [Results]: High VDR expression in tumour stromal fibroblasts was associated with better overall survival (OS) and progression-free survival in CRC, independently of its expression in carcinoma cells. 1,25(OH)2D3 inhibited the protumoural activation of NFs and CAFs and imposed in CAFs a 1,25(OH)2D3-associated gene signature that correlated with longer OS and disease-free survival in CRC. Furthermore, expression of two genes from the signature, CD82 and S100A4, correlated with stromal VDR expression and clinical outcome in our cohort of patients with CRC. | es_ES |
dc.description.abstract | [Conclusions]: 1,25(OH)2D3 has protective effects against CRC through the regulation of stromal fibroblasts. Accordingly, expression of VDR and 1,25(OH)2D3-associated gene signature in stromal fibroblasts predicts a favourable clinical outcome in CRC. Therefore, treatment of patients with CRC with VDR agonists could be explored even in the absence of VDR expression in carcinoma cells. | es_ES |
dc.description.sponsorship | This work was supported by grants from Ministerio de Economía y Competitividad of Spain-Fondo Europeo de Desarrollo Regional (SAF2013-43468-R) and Centro para el Desarrollo Tecnológico Industrial (IDI-20130190) to AM; Comunidad de Madrid (S2010/BMD-2344-Colomics2) to AM, CP and FR and Instituto de Salud Carlos III-Fondo Europeo de Desarrollo Regional to AM (RD12/0036/0021), CP (RD12/0036/0041) and FR (RD12/0036/0051, PT13/0010/0012, PI12/01552). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | BMJ Publishing Group | es_ES |
dc.relation | S2010/BMD-2344/Colomics2 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2013-43468-R | es_ES |
dc.relation.isversionof | Publisher's version | es_ES |
dc.rights | openAccess | es_ES |
dc.title | Vitamin D receptor expression and associated gene signature in tumour stromal fibroblasts predict clinical outcome in colorectal cancer | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1136/gutjnl-2015-310977 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1136/gutjnl-2015-310977 | es_ES |
dc.identifier.e-issn | 1468-3288 | - |
dc.rights.license | http://creativecommons.org/licenses/by-nc/4.0/ | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | es_ES |
dc.contributor.funder | Centro para el Desarrollo Tecnológico Industrial (España) | es_ES |
dc.contributor.funder | Comunidad de Madrid | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100001872 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100012818 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.pmid | 27053631 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | artículo | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
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vitamcolorec.pdf | 10,84 MB | Adobe PDF | Visualizar/Abrir |
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