English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/187829
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Insulin regulates astrocytic glucose handling through cooperation with IGF-I

AuthorsFernández García, Ana María ; Hernandez-Garzón, Edwin; Pérez-Domper, Paloma; Pérez-Álvarez, Alberto; Mederos, Sara; Matsui, Takashi; Santi, Andrea; Trueba Saiz, Ángel; García-Guerra, Lucía; Pose-Utrilla, Julia; Fielitz, Jens; Olson, Eric N.; Fernandez de la Rosa, Ruben; Garcia Garcia, Luis; Pozo, Miguel Angel; Iglesias, Teresa ; Araque, Alfonso ; Soya, Hideaki; Perea, Gertrudis ; Martin, Eduardo D.; Torres Alemán, Ignacio
Issue Date2017
PublisherAmerican Diabetes Association
CitationDiabetes 66(1): 64-74 (2017)
AbstractBrain activity requires a flux of glucose to active regions to sustain increased metabolic demands. Insulin, the main regulator of glucose handling in the body, has been traditionally considered not to intervene in this process. However, we now report that insulin modulates brain glucose metabolism by acting on astrocytes in concert with IGF-I. The cooperation of insulin and IGF-I is needed to recover neuronal activity after hypoglycemia. Analysis of underlying mechanisms show that the combined action of IGF-I and insulin synergistically stimulates a mitogen-activated protein kinase/protein kinase D pathway resulting in translocation of GLUT1 to the cell membrane through multiple protein-protein interactions involving the scaffolding protein GAIP-interacting protein C terminus and the GTPase RAC1. Our observations identify insulin-like peptides as physiological modulators of brain glucose handling, providing further support to consider the brain as a target organ in diabetes.
Publisher version (URL)https://doi.org/10.2337/db16-0861
URIhttp://hdl.handle.net/10261/187829
DOI10.2337/db16-0861
ISSN0012-1797
E-ISSN1939-327X
Appears in Collections:(IIBM) Artículos
(IC) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf59,24 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.