English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/187811
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Antiviral activity of myticin C peptide from mussel: An ancient defense against herpesviruses

AuthorsNovoa, Beatriz ; Romero Jódar, Alejandro; Álvarez, Ángel L.; Moreira, Rebeca ; Pereiro, Patricia ; Costa, M. M. ; Dios, S. ; Estepa, Amparo; Parra, Francisco ; Figueras Huerta, Antonio
Issue Date2016
PublisherAmerican Society for Microbiology
CitationJournal of Virology 90(17): 7692-7702 (2016)
AbstractLittle is known about the antiviral response in mollusks. As in other invertebrates, the interferon signaling pathways have not been identified, and in fact, there is a debate about whether invertebrates possess antiviral immunity similar to that of vertebrates. In marine bivalves, due to their filtering activity, interaction with putative pathogens, including viruses, is very high, suggesting that they should have mechanisms to address these infections. In this study, we confirmed that constitutively expressed molecules in naive mussels confer resistance in oysters to ostreid herpesvirus 1 (OsHV-1) when oyster hemocytes are incubated with mussel hemolymph. Using a proteomic approach, myticin C peptides were identified in both mussel hemolymph and hemocytes. Myticins, antimicrobial peptides that have been previously characterized, were constitutively expressed in a fraction of mussel hemocytes and showed antiviral activity against OsHV-1, suggesting that these molecules could be responsible for the antiviral activity of mussel hemolymph. For the first time, a molecule from a bivalve has shown antiviral activity against a virus affecting mollusks. Moreover, myticin C peptides showed antiviral activity against human herpes simplex viruses 1 (HSV-1) and 2 (HSV-2). In summary, our work sheds light on the invertebrate antiviral immune response with the identification of a molecule with potential biotechnological applications
Description11 pages, 5 figures, 1 table
Publisher version (URL)http://dx.doi.org/10.1128/JVI.00591-16
Appears in Collections:(IIM) Artículos
Files in This Item:
File Description SizeFormat 
Antiviral_activity_2016.pdf2,22 MBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.