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Activities of the "Red Española de Bacterias Lácticas" (Spanish network of LAB)

AuthorsSánchez García, Borja ; Ruas-Madiedo, Patricia
Issue Date14-Jun-2016
Citation21ème colloque du Club des Bactéries Lactiques (2017)
AbstractThe "Red Española de Bacterias Lácticas" -RedBAL- is a network of Spanish researchers working on different aspects of LAB related with the involvement of this bacterial group in food safety and quality, as well as in health. Our raison d'être is to stimulate the exchange of knowledge and the establishment of collaborations among the members, in order to improve our scientific achievements and favors the transfer of Science to Industry and Society. In addition, one of the new bets of redBAL is our opening to other scientific groups, with special emphasis in Latin American countries taking advantage of the use of a common language. Currently our RedBAL is constituted by 197 members, organized in 42 groups belonging to 21 Institutions, among others Universities and different Governmental Research Centers, spread around the Spanish geography. About 30% of the members are young Scientists (pre- and post-doctoral students) who constitute the future in the fascinating research field of LAB. The network started in 2002 and since them we have had several meetings to present our results; the next one will be the 11st and it will take place in Gijón (Asturias) from 28th-30th June (http://www.redbal.es). A number of groups in the RedBAL are devoted to study the interaction of commensal and probiotic bacteria with the human immune system. Scientific studies focused on the role of the human microbiome over human health have generated billions of gigabits of genetic information during the last decade. Prediction of the potential bioactivity of the products encoded by the human gut microbiome, or metaproteome, is the first step for identifying proteins responsible for the molecular interaction between microorganisms and the immune system. We have recently published the Mechanism of Action of the Human Microbiome (MAHMI) database (http://www.mahmi.org) (1), conceived as a resource compiling peptide sequences with a potential immunomodulatory activity. We have shown that the bacterial peptides FR-16 and LR-17 encrypted in extracellular proteins from B. longum DJ010A and B. fragilis YCH46, modulated the immune response towards increases in the Th17 and possibly Th22 cell responses. Moreover, peptide LR-17, but not FR-16, induced secretion of higher concentrations of GM-CSF and IL-1ß, suggesting capability of activating macrophages in strain YCH46 but not in DJ010A (2). These results will be presented in the next oncoming RedBAL2017 meeting.
DescriptionTrabajo presentado en el 21ème colloque du Club des Bactéries Lactiques, celebrado en Lille (Francia) el 14 y 15 de julio de 2017
Appears in Collections:(IPLA) Comunicaciones congresos
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