English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/186688
Share/Impact:
Statistics
logo share SHARE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Protein kinase inhibitors for the treatment of multiple sclerosis

AuthorsMartínez, Ana ; Gil, Carmen
Issue Date28-Jun-2019
PublisherRoyal Society of Chemistry (UK)
CitationRSC-Drug Discovery Series (70) Emerging Drugs and Targets for Multiple Sclerosis. Editor: Ana Martinez. Chapter 8 Pages 170 - 196 (2019)
AbstractDysregulation of the activity of protein kinases has been associated with numerous diseases such as cancer or chronic inflammatory conditions. Therefore, protein kinases are attractive drug targets that are the most intensively pursued by both industrial and academic laboratories, with great success in the cancer field. Today, more than 40 protein kinase inhibitors have been approved for cancer therapy. This success, coupled with a greater understanding of inflammatory signalling cascades and cell death and regeneration pathways, led to kinase inhibitors taking centre stage in the pursuit for new drugs for the treatment of many unmet diseases. Moreover, considering that multiple sclerosis (MS) is classified as an autoimmune disease of the central nervous system (CNS), protein kinases as key drivers of many inflammatory-mediated diseases represent an important and promising class of emerging therapeutic targets for MS. It is only a matter of time to witness whether the modulation of the protein kinases collected in this chapter may become a valuable option for the future treatment of MS.
Description36 p.-5 fig.
Publisher version (URL)https://doi.org/10.1039/9781788016070-00170
URIhttp://hdl.handle.net/10261/186688
DOI10.1039/9781788016070-00170
ISBN978-1-78801-450-2
ISSN2041-3203
Appears in Collections:(CIB) Libros y partes de libros
Files in This Item:
File Description SizeFormat 
Capitulo 8_kinases_08012019 def.docxPostprint713,72 kBMicrosoft Word XMLView/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.