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Title

Fast synthesis and bioconjugation of 68Ga core-doped extremely small iron oxide nanoparticles for PET/MR imaging

AuthorsPellico, Juan; Ruiz-Cabello, Jesús; Saiz-Alía, Marina; Rosario, Gilberto del; Caja, Sergio; Montoya, María; Fernández de Manuel, Laura; Morales, M. P. ; Gutiérrez, Lucía ; Galiana, Beatriz ; Enríquez, José A.; Herranz, Fernando
KeywordsIron Oxide
T1‐MRI
Nano‐radiotracer
PET/MRI
Chelator‐free 68Ga
Issue Date2-Jun-2016
PublisherJohn Wiley & Sons
CitationContrast Media and Molecular Imaging 11(3): 203-210 (2016)
AbstractCombination of complementary imaging techniques, like hybrid PET/MRI, allows protocols to be developed that exploit the best features of both. In order to get the best of these combinations the use of dual probes is highly desirable. On this sense the combination of biocompatible iron oxide nanoparticles and 68Ga isotope is a powerful development for the new generation of hybrid systems and multimodality approaches. Our objective was the synthesis and application of a chelator-free 68Ga-iron oxide nanotracer with improved stability, radiolabeling yield and in vivo performance in dual PET/MRI. We carried out the core doping of iron oxide nanoparticles, without the use of any chelator, by a microwave-driven protocol. The synthesis allowed the production of extremely small (2.5 nm) 68Ga core-doped iron oxide nanoparticles. The microwave approach allowed an extremely fast synthesis with a 90% radiolabeling yield and T1 contrast in MRI. With the same microwave approach the nano-radiotracer was functionalized in a fast and efficient way. We finally evaluated these dual targeting nanoparticles in an angiogenesis murine model by PET/MR imaging.
Publisher version (URL)https://doi.org/10.1002/cmmi.1681
URIhttp://hdl.handle.net/10261/186159
Identifiersdoi: 10.1002/cmmi.1681
e-issn: 1555-4317
issn: 1555-4309
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