Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/186087
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Immunomodulatory and angiogenic responses induced by graphene oxide scaffolds in chronic spinal hemisected rats |
Autor: | López-Dolado, Elisa; González-Mayorga, Ankor; Gutiérrez, María C. CSIC ORCID ; Serrano, María C. CSIC ORCID | Palabras clave: | Scaffold Angiogenesis Graphene oxide Macrophage Spinal cord injury |
Fecha de publicación: | ago-2016 | Editor: | Elsevier | Citación: | Biomaterials 99: 72-81 (2016) | Resumen: | Attractive physic-chemical features of graphene oxide (GO) and promising results in vitro with neural cells encourage its exploration for biomedical applications including neural regeneration. Fueled by previous findings at the subacute state, we herein investigate for the first time chronic tissue responses (at 30 days) to 3D scaffolds composed of partially reduced GO (rGO) when implanted in the injured rat spinal cord. These studies aim to define fibrotic, inflammatory and angiogenic changes at the lesion site induced by the chronic implantation of these porous structures. Injured animals receiving no scaffolds show badly structured lesion zones and more cavities than those carrying rGO materials, thus pointing out a significant role of the scaffolds in injury stabilization and sealing. Notably, GFAP cells and pro-regenerative macrophages are evident at their interface. Moreover, rGO scaffolds support angiogenesis around and, more importantly, inside their structure, with abundant and functional new blood vessels in whose proximities inside the scaffolds some regenerated neuronal axons are found. On the contrary, lesion areas without rGO scaffolds show a diminished quantity of blood vessels and no axons at all. These findings provide a foundation for the usefulness of graphene-based materials in the design of novel biomaterials for spinal cord repair and encourage further investigation for the understanding of neural tissue responses to this kind of materials in vivo. | Versión del editor: | https://doi.org/10.1016/j.biomaterials.2016.05.012 | URI: | http://hdl.handle.net/10261/186087 | DOI: | 10.1016/j.biomaterials.2016.05.012 | Identificadores: | doi: 10.1016/j.biomaterials.2016.05.012 issn: 0142-9612 |
Aparece en las colecciones: | (ICMM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
79
checked on 24-mar-2024
WEB OF SCIENCETM
Citations
73
checked on 27-feb-2024
Page view(s)
176
checked on 29-mar-2024
Download(s)
37
checked on 29-mar-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.