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http://hdl.handle.net/10261/185878
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dc.contributor.author | Río Lagar, Beatriz del | es_ES |
dc.contributor.author | Redruello, Begoña | es_ES |
dc.contributor.author | Ladero Losada, Víctor Manuel | es_ES |
dc.contributor.author | Cal, Santiago | es_ES |
dc.contributor.author | Obaya, Álvaro J. | es_ES |
dc.contributor.author | Álvarez González, Miguel Ángel | es_ES |
dc.date.accessioned | 2019-07-11T07:05:31Z | - |
dc.date.available | 2019-07-11T07:05:31Z | - |
dc.date.issued | 2018-11-19 | - |
dc.identifier.citation | Scientific Reports 8: 17038 (2018) | es_ES |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/10261/185878 | - |
dc.description.abstract | Tyramine, histamine and putrescine are the most commonly detected and most abundant biogenic amines (BA) in food. The consumption of food with high concentrations of these BA is discouraged by the main food safety agencies, but legal limits have only been set for histamine. The present work reports a transcriptomic investigation of the oncogenic potential of the above-mentioned BA, as assessed in the HT29 human intestinal epithelial cell line. Tyramine had a greater effect on the expression of genes involved in tumorigenesis than did histamine or putrescine. Since some of the genes that showed altered expression in tyramine-exposed cells are involved in DNA damage and repair, the effect of this BA on the expression of other genes involved in the DNA damage response was investigated. The results suggest that tyramine might be genotoxic for intestinal cells at concentrations easily found in BA-rich food. Moreover, a role in promoting intestinal cancer cannot be excluded. | es_ES |
dc.description.sponsorship | This work was performed with the financial support of the Spanish Ministry of Economy and Competitiveness (AGL2016-78708-R). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Springer Nature | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2016-78708-R | es_ES |
dc.relation.isversionof | Publisher's version | es_ES |
dc.rights | openAccess | es_ES |
dc.title | An altered gene expression profile in tyramine-exposed intestinal cell cultures supports the genotoxicity of this biogenic amine at dietary concentrations | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1038/s41598-018-35125-9 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1038/s41598-018-35125-9 | es_ES |
dc.rights.license | http://creativecommons.org/licenses/by-nc-sa/4.0/ | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.contributor.orcid | Río Lagar, Beatriz del [0000-0001-8107-1975] | es_ES |
dc.contributor.orcid | Ladero Losada, Víctor Manuel [0000-0002-7613-3745] | es_ES |
dc.contributor.orcid | Cal, Santiago [0000-0003-1587-466X] | es_ES |
dc.contributor.orcid | Obaya, Álvaro J. [0000-0002-4163-2173] | es_ES |
dc.contributor.orcid | Álvarez González, Miguel Ángel [0000-0001-9607-7480] | es_ES |
dc.identifier.pmid | 30451877 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | artículo | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
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Altered_gene.pdf | 1,29 MB | Adobe PDF | Visualizar/Abrir |
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