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dc.contributor.authorChiner-Oms, Álvaroes_ES
dc.contributor.authorSánchez-Busó, Leonores_ES
dc.contributor.authorCorander, Jukkaes_ES
dc.contributor.authorGagneux, S.es_ES
dc.contributor.authorHarris, Simon R.es_ES
dc.contributor.authorYoung, D.es_ES
dc.contributor.authorGonzález-Candelas, Fernandoes_ES
dc.contributor.authorComas, Iñakies_ES
dc.date.accessioned2019-07-05T08:50:16Z-
dc.date.available2019-07-05T08:50:16Z-
dc.date.issued2019-06-12-
dc.identifier.citationScience advances 5(6): eaaw3307 (2019)es_ES
dc.identifier.urihttp://hdl.handle.net/10261/185521-
dc.description14 páginas, 6 figurases_ES
dc.description.abstractModels on how bacterial lineages differentiate increase our understanding of early bacterial speciation events and the genetic loci involved. Here, we analyze the population genomics events leading to the emergence of the tuberculosis pathogen. The emergence is characterized by a combination of recombination events involving core pathogenesis functions and purifying selection on early diverging loci. We identify the phoR gene, the sensor kinase of a two-component system involved in virulence, as a key functional player subject to pervasive positive selection after the divergence of the Mycobacterium tuberculosis complex from its ancestor. Previous evidence showed that phoR mutations played a central role in the adaptation of the pathogen to different host species. Now, we show that phoR mutations have been under selection during the early spread of human tuberculosis, during later expansions, and in ongoing transmission events. Our results show that linking pathogen evolution across evolutionary and epidemiological time scales points to past and present virulence determinants.es_ES
dc.description.sponsorship: This work was funded by projects of the European Research Council (638553-TB-ACCELERATE) and Ministerio de Economía y Competitividad (Spanish government) research grant SAF2016-77346-R (to I.C.); BFU2014-58656-R and BFU2017-89594-R from Ministerio de Economía y Competitividad (Spanish government) and PROMETEO/2016/122 from Generalitat Valenciana (to F.G.-C); and the Swiss National Science Foundation (grants 310030_166687, IZRJZ3_164171, IZLSZ3_170834, and CRSII5_177163), the European Research Council (309540-EVODRTB), and SystemsX.ch (to S.G.). Á.C.-O. is the recipient of an FPU fellowship from Ministerio de Ciencia, Innovación y Universidades FPU13/00913 (Spanish government). L.S.-B. was funded by Wellcome grant number 098051.es_ES
dc.language.isoenges_ES
dc.publisherAmerican Association for the Advancement of Sciencees_ES
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/638553es_ES
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/309540es_ES
dc.relationMINECO/ICTI2013-2016/SAF2016-77346-Res_ES
dc.relationMINECO/ICTI2013-2016/BFU2014-58656-Res_ES
dc.relationMICIU/ICTI2017-2020/BFU2017-89594-Res_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rightsopenAccesses_ES
dc.subjectBacterial lineageses_ES
dc.subjectGenetic locuses_ES
dc.subjectMycobacterium tuberculosis complexeses_ES
dc.subjectPast and presentes_ES
dc.subjectPositive selectiones_ES
dc.subjectRecombination eventses_ES
dc.subjectSensor kinasees_ES
dc.subjectTwo component systemses_ES
dc.titleGenomic determinants of speciation and spread of the Mycobacterium tuberculosis complexes_ES
dc.typeartículoes_ES
dc.identifier.doi10.1126/sciadv.aaw3307-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1126/sciadv.aaw3307es_ES
dc.identifier.e-issn2375-2548-
dc.rights.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/es_ES
dc.contributor.funderEuropean Research Counciles_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderGeneralitat Valencianaes_ES
dc.contributor.funderSwiss National Science Foundationes_ES
dc.contributor.funderMinisterio de Ciencia e Innovación (España)es_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003359es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000781es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004837es_ES
dc.contributor.orcidComas, Iñaki [0000-0001-5504-9408]es_ES
dc.contributor.orcidChiner-Oms, Álvaro [0000-0002-0463-0101]es_ES
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