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A synthetic alternative to natural lecithins with antimicrobial properties

AuthorsPérez, Lourdes ; Infante, María Rosa ; Pons Pons, Ramon; Morán, María del Carmen; Vinardell, M. Pilar ; Mitjans, Montserrat; Pinazo Gassol, Aurora
KeywordsAmmino acid arginine
Biocompatible multifunctional surfactants
Issue Date14-May-2004
CitationColloids and Surfaces B Biointerfaces 35(3-4): 235-242 (2004)
AbstractTwo soft biocompatible cationic surfactants from the amino acid arginine, 1,2-dilauroyl-3-acetylarginyl-rac-glycerol (1212RAc) and 1,2-dimirystoyl-3-acetylarginyl-rac-glycerol (1414RAc), were prepared. Their physicochemical properties show that they can be classified as multifunctional surfactants with self-aggregation behaviour comparable to that of short-chain lecithins. The two surfactants can simultaneously stabilise water-in-oil (W/O) droplets and oil-in-water (O/W) droplets, forming multiple emulsions. They have antimicrobial activity similar to that of conventional cationic surfactants and are as harmless as amphoteric betaines. These surfactants constitute an interesting alternative to the diglycerides and lecithins in formulations that require antimicrobial properties.
Description8 pages, 4 figures, 5 tables.-- PMID: 15261036 [PubMed].-- Printed version published Jun 1, 2004.
Publisher version (URL)http://dx.doi.org/10.1016/j.colsurfb.2004.03.014
Appears in Collections:(IQAC) Artículos
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