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dc.contributor.authorEstévez-Sarmiento, Francisco-
dc.contributor.authorSaid, Mercedes-
dc.contributor.authorBrouard, Ignacio-
dc.contributor.authorLeón, Francisco-
dc.contributor.authorGarcía, Celina-
dc.contributor.authorQuintana, José-
dc.contributor.authorEstévez, Francisco-
dc.date.accessioned2019-07-01T07:00:34Z-
dc.date.available2019-07-01T07:00:34Z-
dc.date.issued2017-11-01-
dc.identifier.citationBioorganic and Medicinal Chemistry 25(21): 6060-6070 (2017)-
dc.identifier.issn0968-0896-
dc.identifier.urihttp://hdl.handle.net/10261/185169-
dc.description.abstractFlavonoids are naturally occurring polyphenolic compounds and are among the most promising anticancer agents. A series of flavonols and their 3-methyl ether derivatives were synthesized and assessed for cytotoxicity. It was found that 3′-hydroxy-3,4′-dimethoxyflavone (flavonoid 7a) displayed strong cytotoxicity against human SK-MEL-1 melanoma cells and blocked tubulin polymerization, but had no significant cytotoxic effects against quiescent or proliferating human peripheral blood mononuclear cells. Our analyses showed that flavonoid 7a induces G2-M cell cycle arrest and apoptosis in melanoma cells which is associated with cytochrome c release and activation of both extrinsic and intrinsic apoptotic pathways of cell death.-
dc.description.sponsorshipThis research was supported in part by the Spanish Ministerio de Economía y Competitividad (MINECO) and the European Regional Development Fund (CTQ2015-63894-P).-
dc.publisherPergamon Press-
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2015-63894-P-
dc.rightsclosedAccess-
dc.subjectMelanoma-
dc.subjectCaspases-
dc.subjectCytotoxicity-
dc.subjectFlavonoids-
dc.subjectApoptosis-
dc.title3′-Hydroxy-3,4′-dimethoxyflavone blocks tubulin polymerization and is a potent apoptotic inducer in human SK-MEL-1 melanoma cells-
dc.typeartículo-
dc.identifier.doi10.1016/j.bmc.2017.09.043-
dc.relation.publisherversionhttps://doi.org/10.1016/j.bmc.2017.09.043-
dc.identifier.e-issn1464-3391-
dc.date.updated2019-07-01T07:00:34Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.contributor.funderEuropean Commission-
dc.contributor.funderMinisterio de Economía y Competitividad (España)-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
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