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http://hdl.handle.net/10261/185169
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Estévez-Sarmiento, Francisco | - |
dc.contributor.author | Said, Mercedes | - |
dc.contributor.author | Brouard, Ignacio | - |
dc.contributor.author | León, Francisco | - |
dc.contributor.author | García, Celina | - |
dc.contributor.author | Quintana, José | - |
dc.contributor.author | Estévez, Francisco | - |
dc.date.accessioned | 2019-07-01T07:00:34Z | - |
dc.date.available | 2019-07-01T07:00:34Z | - |
dc.date.issued | 2017-11-01 | - |
dc.identifier.citation | Bioorganic and Medicinal Chemistry 25(21): 6060-6070 (2017) | - |
dc.identifier.issn | 0968-0896 | - |
dc.identifier.uri | http://hdl.handle.net/10261/185169 | - |
dc.description.abstract | Flavonoids are naturally occurring polyphenolic compounds and are among the most promising anticancer agents. A series of flavonols and their 3-methyl ether derivatives were synthesized and assessed for cytotoxicity. It was found that 3′-hydroxy-3,4′-dimethoxyflavone (flavonoid 7a) displayed strong cytotoxicity against human SK-MEL-1 melanoma cells and blocked tubulin polymerization, but had no significant cytotoxic effects against quiescent or proliferating human peripheral blood mononuclear cells. Our analyses showed that flavonoid 7a induces G2-M cell cycle arrest and apoptosis in melanoma cells which is associated with cytochrome c release and activation of both extrinsic and intrinsic apoptotic pathways of cell death. | - |
dc.description.sponsorship | This research was supported in part by the Spanish Ministerio de Economía y Competitividad (MINECO) and the European Regional Development Fund (CTQ2015-63894-P). | - |
dc.publisher | Pergamon Press | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2015-63894-P | - |
dc.rights | closedAccess | - |
dc.subject | Melanoma | - |
dc.subject | Caspases | - |
dc.subject | Cytotoxicity | - |
dc.subject | Flavonoids | - |
dc.subject | Apoptosis | - |
dc.title | 3′-Hydroxy-3,4′-dimethoxyflavone blocks tubulin polymerization and is a potent apoptotic inducer in human SK-MEL-1 melanoma cells | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1016/j.bmc.2017.09.043 | - |
dc.relation.publisherversion | https://doi.org/10.1016/j.bmc.2017.09.043 | - |
dc.identifier.e-issn | 1464-3391 | - |
dc.date.updated | 2019-07-01T07:00:34Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.contributor.funder | European Commission | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
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