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Título

Allium porrum extract decreases effector cell degranulation and modulates airway epithelial cell function

AutorBenedé, Sara CSIC ORCID; Gradillas, Ana; Villalba, Mayte; Batanero, Eva
Palabras claveAllium porrum
Antioxidant activity
Phenolic compounds
Mast cell
Epithelium
Fecha de publicación8-jun-2019
EditorMultidisciplinary Digital Publishing Institute
CitaciónNutrients 11(6): 1303 (2019)
ResumenAllium genus plants, such as leek (Allium porrum), are rich sources of anti-inflammatory and anti-oxidant secondary metabolites; this is of interest because it demonstrates their suitability as pharmacological alternatives for inflammatory processes, including allergy treatment. The composition of methanolic leek extract (LE) was analyzed by GC–MS and LC–IT/MS, and the total phenolic content and antioxidant capacity were quantified by colorimetric methods. Its pharmacological potential was analyzed in human bronchial epithelial Calu-3 cells, human mast cells LAD2, and humanized rat basophiles RBL-2H3. LE exhibited a cytotoxic effect on Calu-3 cells and HumRBL-2H3 cells only at high concentrations and in a dose-dependent manner. Moreover, LE decreased the degranulation of LAD2 and HumRBL-2H3 cells. LE treatment also significantly prevented alterations in transepithelial electrical resistance values and mRNA levels of glutathione-S-transferase (GST), c-Jun, and NFκB after treatment with H2O2 in ALI-cultured Calu-3 cells. Finally, ALI-cultured Calu-3 cells treated with LE showed lower permeability to Ole e 1 compared to untreated cells. A reduction in IL-6 secretion in ALI-cultured Calu-3 cells treated with LE was also observed. In summary, the results obtained in this work suggest that A. porrum extract may have potential anti-allergic effects due to its antioxidant and anti-inflammatory properties. This study provides several important insights into how LE can protect against allergy.
DescripciónThis article belongs to the Special Issue Edible Fruits and Human Health.
Versión del editorhttps://doi.org/10.3390/nu11061303
URIhttp://hdl.handle.net/10261/185049
DOI10.3390/nu11061303
ISSN2072-6643
E-ISSN2072-6643
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