English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/185044
logo share SHARE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


The Potential Role of Genomic Medicine in the Therapeutic Management of Rheumatoid Arthritis

AuthorsAcosta-Herrera, Marialbert; González-Serna, David; Martín, Javier
Issue Date10-Jun-2019
PublisherMultidisciplinary Digital Publishing Institute
CitationJournal of Clinical Medicine 8 (6): 826 (2019)
AbstractDuring the last decade, important advances have occurred regarding understanding of the pathogenesis and treatment of rheumatoid arthritis (RA). Nevertheless, response to treatment is not universal, and choosing among different therapies is currently based on a trial and error approach. The specific patient’s genetic background influences the response to therapy for many drugs: In this sense, genomic studies on RA have produced promising insights that could help us find an effective therapy for each patient. On the other hand, despite the great knowledge generated regarding the genetics of RA, most of the investigations performed to date have focused on identifying common variants associated with RA, which cannot explain the complete heritability of the disease. In this regard, rare variants could also contribute to this missing heritability as well as act as biomarkers that help in choosing the right therapy. In the present article, different aspects of genetics in the pathogenesis and treatment of RA are reviewed, from large-scale genomic studies to specific rare variant analyses. We also discuss the shared genetic architecture existing among autoimmune diseases and its implications for RA therapy, such as drug repositioning.
Identifiersdoi: 10.3390/jcm8060826
Appears in Collections:Colección MDPI
Files in This Item:
File Description SizeFormat 
jcm-08-00826-v2.pdf295,82 kBAdobe PDFThumbnail
Show full item record
Review this work

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.