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Título: | One-pot synthesis of functionalized carbazoles via a CAN-catalyzed multicomponent process comprising a C–H activation step |
Autor: | González, Juan F.; Rocchi, Damiano; Tejero, Tomás CSIC ORCID; Merino, Pedro CSIC ORCID ; Menéndez, J. Carlos | Fecha de publicación: | 2017 | Editor: | American Chemical Society | Citación: | Journal of Organic Chemistry 82(14): 7492-7502 (2017) | Resumen: | The microwave-promoted three-component reaction between o-nitrochalcones, primary amines and β-dicarbonyl compounds in the presence of Ce(IV) ammonium nitrate constitutes the first example of a multicomponent carbazole synthesis. This reaction furnishes highly substituted and functionalized carbazole derivatives via a double annulation process that generates two C-C and two C-N bonds, with water as the only side product. Mechanistically, this transformation has some unusual features that include an intramolecular coupled hydrogenation-dehydrogenation process, the functionalization of a C-H group by direct attack onto a nitrogen function and a CAN-catalyzed reduction via hydride transfer from ethanol. The mechanisms of these reactions were studied with the aid of computational techniques. | Versión del editor: | https://doi.org/10.1021/acs.joc.7b01199 | URI: | http://hdl.handle.net/10261/184859 | DOI: | 10.1021/acs.joc.7b01199 | ISSN: | 0022-3263 | E-ISSN: | 1520-6904 |
Aparece en las colecciones: | (ISQCH) Artículos |
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