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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/184679
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dc.contributor.authorQuaglio, D.-
dc.contributor.authorZhdanovskaya, N.-
dc.contributor.authorTobajas, Gloria-
dc.contributor.authorCuartas, V.-
dc.contributor.authorBalducci, S.-
dc.contributor.authorChristodoulou, M. S.-
dc.contributor.authorFabrizi, G.-
dc.contributor.authorGargantilla, Marta-
dc.contributor.authorPriego, Eva María-
dc.contributor.authorCarmona Pestania, Á.-
dc.contributor.authorPassarella, D.-
dc.contributor.authorScrepanti, I.-
dc.contributor.authorBotta, B.-
dc.contributor.authorPalermo, R.-
dc.contributor.authorMori, M.-
dc.contributor.authorGhirga, F.-
dc.contributor.authorPeréz-Pérez, María-Jesús-
dc.date.accessioned2019-06-24T09:09:14Z-
dc.date.available2019-06-24T09:09:14Z-
dc.date.issued2019-
dc.identifierdoi: 10.1021/acsmedchemlett.8b00608-
dc.identifierissn: 1948-5875-
dc.identifiere-issn: 1948-5875-
dc.identifier.citationACS Medicinal Chemistry Letters 10: 639-643 (2019)-
dc.identifier.urihttp://hdl.handle.net/10261/184679-
dc.description.abstractBased on hit-likeness and chemical diversity, a number of chalcones and chalcone-mimetic compounds were selected as putative Notch inhibitors. The evaluation of the antiproliferative effect combined with the inhibition of Notch1 expression in KOPTK1 cell line identified compound 18, featuring a tetrahydronaphthalene-based scaffold, as a new promising Notch-blocking agent.-
dc.description.sponsorshipThe authors acknowledge networking contribution by the COST Action CM1407 “Challenging organic syntheses inspired by nature - from natural products chemistry to drug discovery”. V.C. thanks the Universidad del Valle (CIAM- 2017) and the Science, Technology and Innovation Fund- General Royalties System (FCTeI-SGR) under contract BPIN 2013000100007 for a predoctoral fellowship. This work has been supported by Italian Ministry of Education, University and Research - Dipartimenti di Eccellenza - L. 232/2016. This work has been partially supported by a grant from MINECO/ FEDER SAF2015-64629-C2-1-R (to M-J.P.-P and E-M.P), MIUR PNR 2015−2020 (ARS01_00432) (to I.S.), and Sapienza University 2016 Project number RG116154E2- C7A6FB (to I.S.).-
dc.publisherAmerican Chemical Society-
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2015-64629-C2-1-R-
dc.rightsclosedAccess-
dc.subjectCancer-
dc.subjectNotch inhibitors, T-ALL-
dc.subjectChalcone-
dc.subjectTetrahydronaphthalene scaffold-
dc.titleChalcones and Chalcone-mimetic Derivatives as Notch Inhibitors in a Model of T-cell Acute Lymphoblastic Leukemia-
dc.typeartículo-
dc.identifier.doi10.1021/acsmedchemlett.8b00608-
dc.relation.publisherversionhttp://dx.doi.org/10.1021/acsmedchemlett.8b00608-
dc.date.updated2019-06-24T09:09:14Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.contributor.funderEuropean Commission-
dc.contributor.funderSapienza Università di Roma-
dc.contributor.funderMinisterio de Economía y Competitividad (España)-
dc.relation.csicSí-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004271es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.pmid30996810-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
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