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Title

Gemini histidine based surfactants: Characterization; surface properties and biological activity

AuthorsPinazo, Aurora; Pons, Ramon; Bustelo, Marta; Manresa, María Ángeles; Moran, Carmen; Raluy, Miriam; Pérez, Lourdes
KeywordsDNA binbing
Gemini surfactants
Histidine
Self-assembly
Langmuir monolayers
Antimicrobial activity
Hemolytic activity
Issue Date10-Jun-2019
PublisherElsevier
CitationJournal of Molecular Liquids 111156 (2019)
AbstractNew gemini cationic surfactants bearing imidazolium groups as polar heads and alkyl chains of various lengths were prepared using the amino acid histidine as starting material. These surfactants were found to have very low cmc values and reduced the surface tension of water solutions with high efficiency. Their biological properties, antimicrobial and hemolytic activities, depended on the alkyl chain length. These surfactants are active against a wide range of bacteria including methicillin-resistant Staphylococcus aureus (MRSA). Moreover, these gemini surfactants have good DNA binding capacity. These new gemini surfactants show a great potential in cosmetic, food and pharmaceutical industries.
Publisher version (URL)https://doi.org/10.1016/j.molliq.2019.111156
URIhttp://hdl.handle.net/10261/184031
DOI10.1016/j.molliq.2019.111156
Appears in Collections:(IQAC) Artículos
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