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Title

Assessment of the potential irritation and photoirritation of novel amino acid-based surfactants by in vitro methods as alternative to the animal tests

AuthorsBenavides, Tomás; Martínez, Verónica; Mitjans, Montserrat; Infante, María Rosa ; Morán, María del Carmen; Clapés Saborit, Pere ; Clothier, Richard; Vinardell, M. Pilar
KeywordsSurfactants
Phototoxicity
Irritancy
Keratinocytes
Fibroblast
Red blood cells
Issue Date21-May-2004
PublisherElsevier
CitationToxicology 201(1-3): 87-93 (2004)
AbstractThe ultraviolet-A radiation damage effects on skin and eyes will be increased by phototoxic compounds which could be present in pharmaceutical or cosmetic formulations. Great efforts have been made in the last years to find surfactants to replace those with phototoxic potential in commercial use. Series of different in vitro models for phototoxicity, included to validated neutral red uptake (NRU) 3T3 phototoxicity assay are useful screening tools. The phototoxic effects of a novel family of glycerol amino acid-based surfactant compounds were examined via these assays. Human red blood cells and two immortalised cell lines, murine fibroblast cell line 3T3, and one human keratinocyte cell line, HaCaT, were the in vitro models employed to predict potential photoirritation. The phototoxic end-points assessed were hemolysis (human red blood cell test) and resazurin transformation to resorufin and NRU in cell culture methods. The results suggest that no phototoxic effects by any new amino acid derived-surfactants, could be identified.
Description7 pages, 4 figures, 1 table.-- PMID: 15297023 [PubMed].-- Printed version published Sep 1, 2004.
Publisher version (URL)http://dx.doi.org/10.1016/j.tox.2004.04.003
URIhttp://hdl.handle.net/10261/18397
DOI10.1016/j.tox.2004.04.003
ISSN0300-483X
E-ISSN1879-3185
Appears in Collections:(IQAC) Artículos
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