English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/183883
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Gut dysbiosis and neuroimmune responses to brain infection with Theiler’s murine encephalomyelitis virus

AuthorsCarrillo-Salinas, Francisco; Mestre, Leyre ; Mecha, Miriam ; Feliú, Ana; Campo, R. del; Villarrubia, N.; Montalbán, Xavier; Alvarez-Cermeño, José C.; Villar, L.M.
Issue Date14-Mar-2017
PublisherSpringer Nature
CitationScientific Reports 7: 44377 (2017)
AbstractRecent studies have begun to point out the contribution of microbiota to multiple sclerosis (MS) pathogenesis. Theiler’s murine encephalomyelitis virus induced demyelinating disease (TMEV-IDD) is a model of progressive MS. Here, we first analyze the effect of intracerebral infection with TMEV on commensal microbiota and secondly, whether the early microbiota depletion influences the immune responses to TMEV on the acute phase (14 dpi) and its impact on the chronic phase (85 dpi). The intracranial inoculation of TMEV was associated with a moderate dysbiosis. The oral administration of antibiotics (ABX) of broad spectrum modified neuroimmune responses to TMEV dampening brain CD4+ and CD8+ T infiltration during the acute phase. The expression of cytokines, chemokines and VP2 capsid protein was enhanced and accompanied by clusters of activated microglia disseminated throughout the brain. Furthermore, ABX treated mice displayed lower levels of CD4+ and CD8+T cells in cervical and mesenteric lymph nodes. Increased mortality to TMEV was observed after ABX cessation at day 28pi. On the chronic phase, mice that survived after ABX withdrawal and recovered microbiota diversity showed subtle changes in brain cell infiltrates, microglia and gene expression of cytokines. Accordingly, the surviving mice of the group ABX-TMEV displayed similar disease severity than TMEV mice.
Publisher version (URL)https://doi.org/10.1038/srep44377
URIhttp://hdl.handle.net/10261/183883
DOI10.1038/srep44377
E-ISSN2045-2322
Appears in Collections:(IC) Artículos
Files in This Item:
File Description SizeFormat 
srep44377.pdf2,66 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.