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AbrA1/A2, a new piece in the integration of primary metabolism and antibiotic production in Streptomyces coelicolor

AuthorsSánchez de la Nieta, R.; Antoraz, Sergio; Díaz, Margarita ; Santamaría, Ramón I.
Issue Date27-Aug-2018
Citation5th YMS (2018)
AbstractTwo-component systems (TCSs) are included between the most important transduction signal mechanisms in bacteria, and are involved in the coordination of many biological processes. The AbrA1/A2 TCS has been described as a pleiotropic negative regulator of morphological differentiation and antibiotic production in Streptomyces coelicolor1,2 . The analysis of different key genes promoters in primary metabolism, secondary metabolism and morphological differentiation shows the role of AbrA TCS in the regulation of the antibiotic actinorhodin, a putative lantibiotic (SCO0268) and the high affinity phosphate transport system Pst. Furthermore, in this study we have enabled to identify a motif implied in the regulation of Pst system by AbrA. These results place the AbrA TCS as a potential new integration pathway of phosphate metabolism and antibiotic production, alternatively to PhoP/R, the canonical TCS that coordinate these biological processes in bacteria.
DescriptionTrabajo presentado en el 5th Young Microbiologist symposium on Microbe Signalling, Organisation and Pathogenesis (YMS Belfast), celebrado en Belfast (irlanda), los días 27 y 28 de agosto de 2018
Appears in Collections:(IBFG) Comunicaciones congresos
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