English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/182710
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Insights into teleost interferon-gamma biology: An update

AuthorsPereiro, Patricia ; Figueras Huerta, Antonio ; Novoa, Beatriz
Type II interferon
Immune response
Issue Date2019
CitationFish and Shellfish Immunology 90: 150-164 (2019)
AbstractInterferon-gamma (IFN-ϒ) is probably one of the most relevant cytokines orchestrating the immune response in vertebrates. Although the activities mediated by this molecule are well known in mammals, several aspects of the IFN-ϒ system in teleosts remain a riddle to scientists. Numerous studies support a potentially similar role of the fish IFN-ϒ signalling pathway in some well-described immunological processes induced by this cytokine in mammals. Nevertheless, the existence in some teleost species of duplicated ifng genes and an additional gene derived from ifng known as interferon-γ-related (ifngrel), among other things, raises new interesting questions about the mode of action of these various molecules in fish. Moreover, certain IFN-ϒ-mediated activities recently observed in mammals are still fully unknown in fish. Another attractive but mainly unexplored curious property of IFN-ϒ in vertebrates is its potential dual role depending on the type of pathogen. In addition, some aspects mediated by this molecule could favour the resolution of a bacterial infection but be harmful in the context of a viral disease, and vice versa. This review collects old and new aspects of IFN-ϒ research in teleosts and discusses new questions and pathways of investigation based on recent discoveries in mammals
Description15 pages, 3 tables, 3 figures
Publisher version (URL)https://doi.org/10.1016/j.fsi.2019.04.002
Appears in Collections:(IIM) Artículos
Files in This Item:
File Description SizeFormat 
Insights_teleost_2019.pdf Embargoed until July 1, 20201,24 MBAdobe PDFThumbnail
View/Open    Request a copy
Show full item record
Review this work

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.