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Coinfection with HIV and hepatitis C virus in 229 children and young adults living in Europe

AuthorsThorne, Claire; Turkova, Anna; Indolfi, Giuseppe; Venturini, Elisabetta; Giaquinto, Carlo; Goetghebuer, Tessa; Hainaut, Marc; Van Der Kelen, Evelyne; Königs, Christoph; Mantzsch, Kathleen; Baumann, Ulrich; de Martino, Maurizio; Galli, Luisa; Giacomet, Vania; Nicolini, Laura Ambra; Del Puente, Filippo; Gabiano, Clara; Guarino, Alfredo; Martinazzi, Silvia; Miniaci, Angela; Dobsz, Sabina; Marczynska, Magdalena; Ene, Luminita; Duiculescu, Dan; Miloenko, Milana; Dodonov, Konstantin; Latysheva, Inga; Voronin, Evgeny; Rojo, Pablo; Ramos, José Tomás; Navarro, Marisa; Jiménez de Ory, Santiago; Sainz, Talia; Mellado, María J.; García, Miluca; Pérez, Carlos; Moreno, David; Nuñez, Esmeralda; Gracia, Mercedes; Terol, Pedro; Neth, Olaf; Falcón Neyra, Lola; Otero, Carmen; Rincón, Elena; Gavilán, César; López, Carmen; Santos, Juan Luis; Couceiro, José; Noguera-Julián, Antoni; Fortuny, Claudia; Soler-Palacin, Pere; Espiau, María; Mur, Antonio; Coll, María T.; Valmanya, María T.; Mayol, Luis; Méndez, María J.; Rodrigo, Carlos; Escribano, Joaquín; Rius, Neus; Rovira, Núria; Calavia, Olga; García, Lourdes; Pineda, Valentí; Soriano-Arandes, Antoni; Rudin, Christoph; Duppenthaler, Andrea; Judd, Ali; Malyuta, Ruslan; Volokha, Alla; Raus, Irina; Kaleeva, T.; Baryshnikova, Y.; Soloha, Svetlana; Bashkatova, N.; Glutshenko, O.; Ruban, Z.; Primak, Natalia; Kiseleva, Galina
Hepatitis C
Vertical infection
Issue DateJan-2017
PublisherLippincott Williams & Wilkins
CitationAIDS 31(1): 127-135 (2017)
Abstract[Objective] To characterize children, adolescents and young adults infected with HIV/hepatitis C virus (HCV) vertically or before age of 18 years and living in Europe regarding mode of acquisition, HCV genotype, clinical status and treatment.
[Design] Retrospective, cross-sectional study using pooled data from 11 European paediatric HIV cohorts.
[Methods] Patients aged more than 18 months and less than 25 years, with HIV/HCV acquired vertically or in childhood, were included. Anonymized individual patient data were collected using a standard protocol and modified HIV Cohorts Data Exchange Protocol.
[Results] Of 229 patients included, 142 (62%) had vertically acquired infection. Median age at last follow-up was 16.2 years. Most children had HCV genotype 1 (101/184, 55%) or 3 (57/184, 31%). One-fifth (46/214) had a previous AIDS diagnosis (data missing on prior AIDS diagnoses for 15). At their last clinic visit, 70% (145/208) had no/mild immunosuppression (Centers for Disease Control and Prevention stage 1), and 131 of 179 on antiretroviral therapy had undetectable HIV RNA (assay thresholds varied from <20 to <150 copies/ml). Overall, 42% (86/204) had hepatomegaly in the previous year, and 55% (116/213) had alanine aminotransferase more than 40 IU/l at their last test. Of 97 patients with transient elastography, 12 had results more than 9 kPa; this was associated with duration of HCV infection (P = 0.033), but not with CD4+ cell count, antiretroviral therapy use or sex in univariable analysis. Of 17 patients with liver biopsies, six had bridging fibrosis and one had cirrhosis. Twenty-five (11%) had been treated successfully for HCV.
[Conclusion] The high proportion of patients with progressive liver disease underscores the need for close monitoring and earlier and more effective HCV treatment.
Publisher version (URL)https://doi.org/10.1097/QAD.0000000000001285
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