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Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/18209
Title: Origin of the response of nanomechanical resonators to bacteria adsorption
Authors: Ramos Vega, Daniel ; Tamayo de Miguel, Francisco Javier ; Mertens, Johann ; Calleja, Montserrat ; Zaballos, Ángel
Keywords: Cellular biophysics
Biological techniques
Issue Date: 30-Nov-2006
Publisher: American Institute of Physics
Citation: Journal of Applied Physics 100, 106105 (2006)
Abstract: Resonant microcantilevers are being actively investigated as sensitive mass sensors for biological detection. By performing experiments of adsorption of the bacteria Escherichia coli on singly clamped microcantilevers, we demonstrate that the effect of the added mass is not the only and may not be the main origin of the response of these sensors. The experiments show that the magnitude and sign of resonance frequency shift both depend critically on the distribution of the adsorbed bacterial cells on the cantilever. We relate this behavior to the added mass that shifts the resonance to lower frequencies and the higher effective flexural rigidity of the cantilever due to the bacteria stiffness that shifts the resonance to higher frequencies. Both effects can be uncoupled by positioning the cells where each effect dominates, near the free cantilever end for measuring the added mass or near the clamping for measuring the increase of flexural rigidity.
Publisher version (URL): http://link.aip.org/link/?JAPIAU/100/106105/1
URI: http://hdl.handle.net/10261/18209
DOI: 10.1063/1.2370507
ISSN: 0021-8979
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