English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/182020
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

The Drosophila Hox gene Ultrabithorax controls appendage shape by regulating extracellular matrix dynamics.

AuthorsDe las Heras, José M.; García-Cortés, Celia; Foronda, David ; Pastor-Pareja, José Carlos; Shashidhara, L.S.; Sánchez-Herrero, Ernesto
KeywordsOrgan shape
Ultrabithorax
Matrix metalloproteinases
Hox genes
Extracellular matrix
Drosophila
Issue Date17-May-2018
PublisherCompany of Biologists
CitationDevelopment 145: 1 (2018)
AbstractAlthough the specific form of an organ is frequently important for its function, the mechanisms underlying organ shape are largely unknown. In Drosophila, the wings and halteres, homologous appendages of the second and third thoracic segments, respectively, bear different forms: wings are flat, whereas halteres are globular, and yet both characteristic shapes are essential for a normal flight. The Hox gene Ultrabithorax (Ubx) governs the difference between wing and haltere development, but how Ubx function in the appendages prevents or allows flat or globular shapes is unknown. Here, we show that Ubx downregulates Matrix metalloproteinase 1 (Mmp1) expression in the haltere pouch at early pupal stage, which in turn prevents the rapid clearance of Collagen IV compared with the wing disc. This difference is instrumental in determining cell shape changes, expansion of the disc and apposition of dorsal and ventral layers, all of these phenotypic traits being characteristic of wing pouch development. Our results suggest that Ubx regulates organ shape by controlling Mmp1 expression, and the extent and timing of extracellular matrix degradation
URIhttp://hdl.handle.net/10261/182020
Identifiersdoi: 10.1242/dev.161844
issn: 0950-1991
Appears in Collections:(CBM) Artículos
Files in This Item:
File Description SizeFormat 
Sánchez-HerreroE_TheDrosophilaHox.pdf7,16 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.