Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/181494
COMPARTIR / EXPORTAR:
SHARE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Multicomponent synthesis of γ-nitrocomponds under on water conditions |
Autor: | Prieto-Ramírez, Mary Cruz CSIC; Armas, Pedro de CSIC; García-Tellado, Fernando CSIC ORCID | Fecha de publicación: | 12-jul-2015 | Citación: | 19th European Symposium of Organic Chemistry (2015) | Resumen: | Multicomponent reactions are the most efficient chemical procedures for the synthetic preparation of highly functionalized organic compounds. They take place from raw materials, with great economy of atom, energy-efficient and without intermediate purification steps. That is why the multicomponent reactions, particularly asymmetric multicomponent are of great interest. We have developed a new methodology multicomponent, organocatalytic and scalable which operates in the organic-water interface (conditions >on water>; OW)[2] to obtain γ-nitrocompounds from an aldehyde, a 1,3-dicarbonyl species and a nitroalkane. The reaction proceeds in two steps, a first step in which the 1,3-dicarbonyl species reacts with the aldehyde, resulting in the Knoevenagel adduct and a second step in which the nucleophile nitroalkane is added to this adduct, through a Michael addition. The process requires the presence of catalytic amounts of a thiourea derivative or squaramide (catalyst) and base N,N-Dimethylcyclohexylamine and generates γ-nitroesters featuring three contiguous stereocenters in a single reaction step (see figure 1). These products are suitable γ-amino acid precursor. | Descripción: | Trabajo presentado en el 19th European Symposium of Organic Chemistry, celebrado en Lisboa del 12 al 16 de julio de 2015. | URI: | http://hdl.handle.net/10261/181494 |
Aparece en las colecciones: | (IPNA) Comunicaciones congresos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
Page view(s)
154
checked on 23-abr-2024
Download(s)
37
checked on 23-abr-2024
Google ScholarTM
Check
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.