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Phenolic compounds from Brazilian propolis with pharmacological activities

AuthorsMarcucci, María Cristina; Ferreres, Federico ; García-Viguera, Cristina ; Bankoba, V. S.; Castro, de S. L; Dantas, A. P.; Valente, P. H. M.; Paulino, Niraldo
Antibacterial activity
Antitrypanosomal activity
Phenolic compounds
Relaxant effect
Issue DateFeb-2001
CitationJournal of Ethnopharmacology 74(2): 105-112 (2001)
AbstractFour compounds were isolated from Brazilian propolis. They are identified as: (1) 3-prenyl-4-hydroxycinnamic acid (PHCA), (2) 2,2-dimethyl-6-carboxyethenyl-2H-1-benzopyrane (DCBEN), (3) 3,5-diprenyl-4-hydroxycinnamic acid (DHCA), and (4) 2,2-dimethyl-6-carboxyethenyl-8-prenyl-2H-1-benzopyran (DPB). The structures of the compounds were determined by MS and NMR techniques. All compounds were assayed against Trypanosoma cruzi and the bacteria Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus faecalis. Compounds (1) to (4) were active against T. cruzi. Except (1), all compounds presented activity against the bacteria tested. When compounds (1)–(3) were tested in the guinea pig isolated trachea, all induced a relaxant effect similar to propolis extract.
Description8 pages, 1 figure, 3 tables.
Publisher version (URL)http://dx.doi.org/10.1016/S0378-8741(00)00326-3
Appears in Collections:(CEBAS) Artículos
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