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Title

The road from host-defense peptides to a new generation of antimicrobial drugs

AuthorsBoto, Alicia ; Pérez de Lastra, José Manuel ; González Martín, Concepción C.
KeywordsTag-and-modify
Gene mining
Customizable units
Antimicrobial
Peptide modification
Site-selective
Cathelicidins
AMP
Peptides
Antibiotic
Issue Date1-Feb-2018
PublisherMolecular Diversity Preservation International
CitationMolecules 23(2): 311 (2018)
AbstractHost-defense peptides, also called antimicrobial peptides (AMPs), whose protective action has been used by animals for millions of years, fulfill many requirements of the pharmaceutical industry, such as: (1) broad spectrum of activity; (2) unlike classic antibiotics, they induce very little resistance; (3) they act synergically with conventional antibiotics; (4) they neutralize endotoxins and are active in animal models. However, it is considered that many natural peptides are not suitable for drug development due to stability and biodisponibility problems, or high production costs. This review describes the efforts to overcome these problems and develop new antimicrobial drugs from these peptides or inspired by them. The discovery process of natural AMPs is discussed, as well as the development of synthetic analogs with improved pharmacological properties. The production of these compounds at acceptable costs, using different chemical and biotechnological methods, is also commented. Once these challenges are overcome, a new generation of versatile, potent and long-lasting antimicrobial drugs is expected.
Publisher version (URL)https://doi.org/10.3390/molecules23020311
URIhttp://hdl.handle.net/10261/181245
Identifiersdoi: 10.3390/molecules23020311
issn: 1420-3049
Appears in Collections:(IPNA) Artículos
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