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Title

Protective effects of epoxypukalide on pancreatic beta-cells and glucose metabolism in STZ-induced diabetic mice

AuthorsLópez-Acosta, José Francisco ; Villa-Pérez, Pablo; Fernández-Díaz, C. ; Román, Daniel de Luis; Díaz-Marrero, Ana R. ; Cueto, Mercedes ; Perdomo, Germán; Cózar-Castellano, Irene
KeywordsDiabetes
Epoxypukalide
Hypoglycaemic agent
Pancreatic β-cells
Issue DateApr-2015
PublisherTaylor & Francis
CitationIslets 7(2): e1078053 1-5 (2015)
AbstractDiabetes is a consequence of a decrease on functional β-cell mass. We have recently demonstrated that epoxypukalide (Epoxy) is a natural compound with beneficial effects on primary cultures of rat islets. In this study, we extend our previous investigations to test the hypothesis that Epoxy protects β-cells and improves glucose metabolism in STZ-induced diabetic mice. We used 3-months old male mice that were treated with Epoxy at 200 μg/kg body weight. Glucose intolerance was induced by multiple intraperitoneal low-doses of streptozotocin (STZ) on 5 consecutive days. Glucose homeostasis was evaluated measuring plasma insulin levels and glucose tolerance. Histomorphometry was used to quantify the number of pancreatic β-cells per islet. β-cell proliferation was assessed by BrdU incorporation, and apoptosis by TUNEL staining. Epoxy treatment significantly improved glucose tolerance and plasma insulin levels. These metabolic changes were associated with increased β-cell numbers, as a result of a two-fold increase in β-cell proliferation and a 50% decrease in β-cell death. Our results demonstrate that Epoxy improves whole-body glucose homeostasis by preventing pancreatic β-cell death due to STZ-induced toxicity in STZ-treated mice.
Publisher version (URL)https://doi.org/10.1080/19382014.2015.1078053
URIhttp://hdl.handle.net/10261/181223
DOI10.1080/19382014.2015.1078053
ISSN1938-2014
E-ISSN1938-2022
Appears in Collections:(IBGM) Artículos
(IPNA) Artículos
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